Changes in the endurance shuttle walk test in COPD patients with chronic respiratory failure after pulmonary rehabilitation: the minimal important difference obtained with anchor- and distribution-based method

Respiratory Research

Johan B Wempe¹  Peter J Wijkstra¹  Mathieu HG de Greef²  Huib AM Kerstjens¹  Nick HT ten Hacken¹  Marieke L Duiverman³  Wytske A Altenburg¹ 

[1] University of Groningen, University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands;University of Groningen, University Medical Centre Groningen, Institute of Human Movement Sciences, Groningen, the Netherlands;University of Groningen, University Medical Centre Groningen, Department of Pulmonary Diseases, Groningen, the Netherlands

关键词: Respiratory failure;    COPD;    Minimally important difference;    Endurance shuttle walk test;   

Others  :  1133335
DOI  :  10.1186/s12931-015-0182-x

 received in 2014-09-26, accepted in 2015-01-26,  发布年份 2015

【 摘 要 】

Background

Although the endurance shuttle walk test (ESWT) has proven to be responsive to change in exercise capacity after pulmonary rehabilitation (PR) for COPD, the minimally important difference (MID) has not yet been established. We aimed to establish the MID of the ESWT in patients with severe COPD and chronic hypercapnic respiratory failure following PR.

Methods

Data were derived from a randomized controlled trial, investigating the value of noninvasive positive pressure ventilation added to PR. Fifty-five patients with stable COPD, GOLD stage IV, with chronic respiratory failure were included (mean (SD) FEV₁ 31.1 (12.0) % pred, age 62 (9) y). MID estimates of the ESWT in seconds, percentage and meters change were calculated with anchor based and distribution based methods. Six minute walking distance (6MWD), peak work rate on bicycle ergometry (Wpeak) and Chronic Respiratory Questionnaire (CRQ) were used as anchors and Cohen’s effect size was used as distribution based method.

Results

The estimated MID of the ESWT with the different anchors ranged from 186–199 s, 76–82% and 154–164 m. Using the distribution based method the MID was 144 s, 61% and 137 m.

Conclusions

Estimates of the MID for the ESWT after PR showed only small differences using different anchors in patients with COPD and chronic respiratory failure. Therefore we recommend using a range of 186–199 s, 76–82% or 154–164 m as MID of the ESWT in COPD patients with chronic respiratory failure. Further research in larger populations should elucidate whether this cut-off value is also valid in other COPD populations and with other interventions.

Trial registration

ClinicalTrials.Gov (ID NCT00135538 webcite).

【 授权许可】

   
2015 Altenburg et al.; licensee BioMed Central.

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