An overview of HCV molecular biology, replication and immune responses

Virology Journal

Sheikh Riazuddin³  Zafar Nawaz¹  Sidra Rehman²  Tariq Javed²  Usman A Ashfaq² 

[1]Braman Family Breast Cancer Institute, University of Miami, USA

[2]Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan

[3]Allama Iqbal Medical College, University of Health sciences, Lahore

关键词: immune responses;    HCV entry;    replication;    HCV;   

Others  :  1156850
DOI  :  10.1186/1743-422X-8-161

 received in 2011-02-10, accepted in 2011-04-11,  发布年份 2011

【 摘 要 】

Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon α in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. In this review, we summarize molecular virology, replication and immune responses against HCV and discussed how HCV escape from adaptive and humoral immune responses. This advance knowledge will be helpful for development of vaccine against HCV and discovery of new medicines both from synthetic chemistry and natural sources.

【 授权许可】

   
2011 Ashfaq et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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