Relationship of vitamin D status and bone mass according to vitamin D-binding protein genotypes

Nutrition Journal

Boonsong Ongphiphadhanakul³  Piyamitr Sritara³  Wipa Ratanachaiwong²  Suwannee Chanprasertyothin³  La-or Chailurkit³  Chanika Sritara¹  Hataikarn Nimitphong³ 

[1] Department of Radiology, Ramathibodi Hospital, Mahidol University, Rama VI Road, Ratchathewi 10400, Bangkok, Thailand;Health Office, Electricity Generating Authority of Thailand, Nonthaburi 11130, Thailand;Department of Medicine and Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Ratchathewi 10400, Bangkok, Thailand

关键词: DBP rs2282679 genotypes;    25(OH)D;    Fetuin-A;    Bone turnover markers;    BMD;   

Others  :  1171506
DOI  :  10.1186/s12937-015-0016-1

 received in 2014-12-12, accepted in 2015-03-03,  发布年份 2015

【 摘 要 】

Background

Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [25(OH)D]; this could influence on the effects of vitamin D in relation to bone mineral density (BMD) and fractures. Emerging data suggest that fetuin-A may be involved in bone metabolism. We aimed to investigate the influence of DBP gene polymorphism on the relationship of vitamin D status and fetuin-A levels to BMD and bone markers.

Methods

This cross-sectional study was part of a health survey of employees of the Electricity Generating Authority of Thailand (1,734 healthy subjects, 72% male). Fasting blood samples were assayed for 25(OH)D, fetuin-A, N-terminal propeptides of type 1 procollagen (P1NP), C-terminal cross-linking telopeptides of type I collagen (CTx-I), and DBP rs2282679 genotypes. L1–L4 lumbar spine and femoral BMD were measured using dual-energy X-ray absorptiometry.

Results

The DBP rs2282679 genotype distribution conformed to the Hardy–Weinberg equilibrium. There were no correlations between 25(OH)D levels and BMD and bone markers. But a trend of positive correlation was observed for the DBP genotypes with total hip BMD, and for the interaction between 25(OH)D and DBP genotypes with BMD at all femoral sites. We further analyzed data according to DBP genotypes. Only in subjects with the AA (common) genotype, 25(OH)D levels were positively related to BMD and bone markers, while fetuin-A was negatively related to total hip BMD, independently of age, gender and BMI.

Conclusions

The interaction between vitamin D status, as measured by circulating 25(OH)D and DBP rs2282679 genotypes, modified the association between 25(OH)D and BMD and bone markers. Differences in DBP genotypes additionally influenced the correlation of fetuin-A levels with femoral BMD.

【 授权许可】

   
2015 Nimitphong et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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