Sublobectomy versus Lobectomy for stage IA (T1a) non-small-cell lung cancer: a meta-analysis study

World Journal of Surgical Oncology

Shanqing Li²  Yeye Chen¹  Hongsheng Liu¹  Cheng Huang¹  Yaxin Liu² 

[1] Department of Thoracic Surgery, Peking Union Medical College Hospital, Shuaifuyuan No.1 Dongcheng District, Beijing 100730, China;Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No.1 Dongcheng District, Beijing 100730, China

关键词: Overall Survival (OS);    Meta-analysis;    Non-Small-Cell lung Cancer;    Lobectomy;    Sublobectomy;   

Others  :  811951
DOI  :  10.1186/1477-7819-12-138

 received in 2013-10-31, accepted in 2014-04-11,  发布年份 2014

【 摘 要 】

Background

Although lobectomy is considered the standard surgical treatment for the majority of patients with non-small-cell lung cancer (NSCLC), the operation project for patients with stage IA NSCLC (T1a, tumor diameter ≤2 cm) remains controversial. Sublobectomy is appropriate only in certain patients as many doctors consider it to be overtreatment. We evaluated the five-year overall survival rate of sublobectomy and lobectomy for stage IA NSCLC (T1a, tumor diameter ≤2 cm) through a meta-analysis.

Methods

The five-year overall survival rate (OS) of stage IA (T1a) NSCLC after sublobectomy (including wedge resection and segmentectomy) and lobectomy were compared. We also compared the OS of stage IA (T1a) NSCLC after segmentectomy and lobectomy. The log (hazard ratio, ln (HR)) and its standard error (SE) were used as the outcome measure for data combining.

Results

There were 12 eligible studies published between 1994 and 2013 in which the total number of participants was 18,720. When compared to lobectomy, there was a statistically significant difference of sublobectomy on OS of stage IA (T1a) NSCLC patients (HR 1.38; 95% confidence interval (95% CI), 1.19 to 1.61; P <0.0001). For the comparison between segmentectomy and lobectomy, there was also a statistically significant difference of segmentectomy alone on OS of stage IA (T1a) NSCLC patients (HR 1.48; 95% CI: 1.27 to 1.73; P <0.00001)

Conclusions

We have concluded that in stage IA (T1a) patients sublobectomy, including segmentectomy and wedge resection, causes a lower survival rate than lobectomy.

【 授权许可】

   
2014 Liu et al.; licensee BioMed Central Ltd.

【 图 表 】

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