Compensability index for compensation radiotherapy after treatment interruptions

Radiation Oncology

Ludwig Plasswilm²  Daniel Aebersold¹  Michael Schmuecking¹  Paul Martin Putora² 

[1] Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, Bern, 3010, Switzerland;Department of Radiation Oncology, Kantonsspital St. Gallen, Rorschacherstrasse 95, St. Gallen, 9000, Switzerland

关键词: Compensability index;    Compensation;    Brake;    Treatment;    Interruption;    Radiation;    Radiotherapy;   

Others  :  1154943
DOI  :  10.1186/1748-717X-7-208

 received in 2012-08-21, accepted in 2012-11-23,  发布年份 2012

【 摘 要 】

Background

The goal of our work was to develop a simple method to evaluate a compensation treatment after unplanned treatment interruptions with respect to their tumour- and normal tissue effect.

Methods

We developed a software tool in java programming language based on existing recommendations to compensate for treatment interruptions. In order to express and visualize the deviations from the originally planned tumour and normal tissue effects we defined the compensability index.

Results

The compensability index represents an evaluation of the suitability of compensatory radiotherapy in a single number based on the number of days used for compensation and the preference of preserving the originally planned tumour effect or not exceeding the originally planned normal tissue effect. An automated tool provides a method for quick evaluation of compensation treatments.

Conclusions

The compensability index calculation may serve as a decision support system based on existing and established recommendations.

【 授权许可】

   
2012 Putora et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Delaney G, Jacob S, Featherstone C, Barton M: The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005, 104:1129-1137.
• [2]Harper JW, Elledge SJ: The DNA damage response: ten years after. Moll Cell 2007, 28:739-745.
• [3]Dörr W: Radiobiological models of normal tissue reactions. hlenther Onkol 1998, 174(Suppl 3):4-7.
• [4]Chadwick KH, Leenhouts HP: A molecular theory of cell survival. Phys Med Biol 1973, 18:78-87.
• [5]Curtis SB: Lethal and potentially lethal lesions induced by radiation - a unified repair model. Radiat Res 1986, 106:252-270.
• [6]Marples B, Joiner MC: The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population. Radiat Res 1993, 133:41-51.
• [7]Gao M, Mayr NA, Huang Z, Zhang H, Wang JZ: When tumor repopulation starts? The onset time of prostate cancer during radiation therapy. Acta Oncol 2010, 49(8):1269-1275.
• [8]Harriss-Phillips WM, Bezak E, Yeoh EK: Monte Carlo radiotherapy simulations of accelerated repopulation and reoxygenation for hypoxic head and neck cancer. Br J Radiol 2011, 84(1006):903-918.
• [9]Royal College of Radiologists: The timely delivery of radical radiotherapy: standards and guidelines for the management of unscheduled treatment interruptions. 2008. [Third edition] https://www.rcr.ac.uk/docs/oncology/pdf/BFCO(08)6_Interruptions.pdf webcite. [Online] 2008
• [10]Ling CC, Humm J, Larson S, Amols H, Fuks Z, Leibel S, Koutcher JA: Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality. Int J Radiat Oncol Biol Phys 2000, 47(3):551-560.
• [11]Petersen C, Zips D, Krause M, Schöne K, Eicheler W, Hoinkis C, Thames HD, Baumann M: Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation. Int J Radiat Oncol Biol Phys 2001, 51(2):483-493.
• [12]Baumann M, Petersen C, Schulz P, Baisch H: Impact of overall treatment time on local control of slow growing human GL squamous cell carcinoma in nude mice treated by fractionated irradiation. Radiother Oncol 1999, 50(1):107-111.
• [13]Putora PM, Fornaro J, Schiefer J, Brügge D, Plasswilm L: Radiotherapy treatment interruption compensation calculator for android based mobile devices. Strahlenther Onkol 2011, 187(8):518.