IMRT treatment plans and functional planning with functional lung imaging from 4D-CT for thoracic cancer patients

Radiation Oncology

Geoffrey G Zhang²  Tzu-Ching Shih⁴  Ji-An Liang¹  Chun-Ru Chien¹  Chien-Yi Hsiao³  Tzung-Chi Huang⁴ 

[1] Radiation Oncology, China Medical University Hospital, Taichung City, Taiwan;Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA;Division of Radiation Therapy & Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei City, Taiwan;Department of Biomedical Imaging and Radiological Science, China Medical University, 91, Hsueh-Shih Road, Taichung City, Taiwan

关键词: IMRT treatment plan;    Functional lung;    Deformable image registration;    4D-CT;   

Others  :  1154798
DOI  :  10.1186/1748-717X-8-3

 received in 2012-08-02, accepted in 2012-12-29,  发布年份 2013

【 摘 要 】

Background and purpose

Currently, the inhomogeneity of the pulmonary function is not considered when treatment plans are generated in thoracic cancer radiotherapy. This study evaluates the dose of treatment plans on highly-functional volumes and performs functional treatment planning by incorporation of ventilation data from 4D-CT.

Materials and methods

Eleven patients were included in this retrospective study. Ventilation was calculated using 4D-CT. Two treatment plans were generated for each case, the first one without the incorporation of the ventilation and the second with it. The dose of the first plans was overlapped with the ventilation and analyzed. Highly-functional regions were avoided in the second treatment plans.

Results

For small targets in the first plans (PTV < 400 cc, 6 cases), all V5, V20 and the mean lung dose values for the highly-functional regions were lower than that of the total lung. For large targets, two out of five cases had higher V5 and V20 values for the highly-functional regions. All the second plans were within constraints.

Conclusion

Radiation treatments affect functional lung more seriously in large tumor cases. With compromise of dose to other critical organs, functional treatment planning to reduce dose in highly-functional lung volumes can be achieved

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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