Oxidative Stress in Asthma

World Allergy Organization Journal

Omer Kalayci¹  Cansin Sackesen¹  Serpil Erzurum²  Esra Birben¹  Umit M Sahiner¹ 

[1] Pediatric Allergy and Asthma Unit, Department of Pediatrics;Respiratory Institute, Cleveland Clinic, Cleveland, Ohio

关键词: redox;    reactive oxygen species;    oxidative stress;    asthma;   

Others  :  1145539
DOI  :  10.1097/WOX.0b013e318232389e

【 摘 要 】

Asthma is a chronic inflammatory lung disease that results in airflow limitation, hyperreactivity, and airway remodeling. There is strong evidence that an imbalance between the reducing and oxidizing systems favoring a more oxidative state is present in asthma. Endogenous and exogenous reactive oxygen species, such as superoxide anion, hydroxyl radical, hypohalite radical, and hydrogen peroxide, and reactive nitrogen species, such as nitric oxide, peroxynitrite, and nitrite, play a major role in the airway inflammation and are determinants of asthma severity. Asthma is also associated with decreased antioxidant defenses, such as superoxide dismutase, catalase, and glutathione. In this review, we will summarize the current knowledge and discuss the current and future strategies for the modulation of oxidative stress in asthma.

【 授权许可】

   
2011 World Allergy Organization; licensee BioMed Central Ltd.

【 图 表 】

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