The survival outcomes and prognosis of stage IV non-small-cell lung cancer treated with thoracic three-dimensional radiotherapy combined with chemotherapy

Radiation Oncology

Yu Wang¹  ZhiYong Wang¹  HuiQin Li¹  QingSong Li¹  Bing Lu²  Zhu Ma¹  WeiWei Ouyang¹  YinXiang Hu¹  ShengFa Su¹ 

[1] Department of Thoracic Oncology, Affiliated Hospital of Guiyang Medical College; and Guizhou Cancer Hospital, Guizhou, People’s Republic of China;Department of Thoracic Oncology, Gui zhou Cancer Hospital, 1 Beijing Road West, Guiyang 550004, People’s Republic of China

关键词: Prognosis;    Three-dimensional radiotherapy;    Stage IV;    Non-small cell lung cancer;   

Others  :  1228534
DOI  :  10.1186/s13014-014-0290-7

 received in 2014-08-12, accepted in 2014-12-04,  发布年份 2014

【 摘 要 】

Background

The impact of thoracic three-dimensional radiotherapy on the prognosis for stage IV non-small-cell lung cancer is unclear. This study is to investigate survival outcomes and prognosis in patients with stage IV non-small cell lung cancer (NSCLC) treated with thoracic three-dimensional radiotherapy and systemic chemotherapy.

Methods

Ninety three patients with stage IV NSCLC had received at least four cycles of chemotherapy and thoracic three-dimensional radiotherapy of ≥40 Gy on primary tumors. The data from these patients were retrospectively analyzed.

Results

Of the 93 patients, the median survival time (MST) was 14.0 months, and the 1, 2, and 3-year survival rates were 54.8%, 20.4%, and 12.9%, respectively. The MST of patients received radiation dose to primary tumor ≥63Gy and <63 Gy for primary tumor were 15.0 and 8.0 months, respectively (P = 0.001). Patients had metastasis to a single site and lower tumor volume (<170 cm³) also produced longer overall survival time (P = 0.002, P = 0.020, respectively). For patients with metastasis at a single site, thoracic radiation dose ≥63 Gy remained a prognostic factor for better overall survival (P = 0.030); patients with metastases at multiple sites, radiation dose ≥63 Gy had a trend to improve overall survival (P = 0.062). A multivariate analysis showed that radiation dose ≥63 Gy (P = 0.017) and metastasis to a single site (P = 0.038) are associated with better overall survival, and the volume of primary tumor was marginally correlated with OS (P = 0.054).

Conclusions

In combination with systemic chemotherapy, radiation dose ≥63 Gy on primary tumor and metastasis to a single site are significant factors for better OS, aggressive thoracic radiotherapy may have an important role in improving OS.

【 授权许可】

   
2014 Su et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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