Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input

Neural Development

William Guido⁵  Michael A. Fox²  Martha E. Bickford⁵  Emily K. Dilger¹  Thomas E. Krahe³  Rana N. El-Danaf⁴ 

[1] Society for Neuroscience, Washington D.C. 20005, USA;Department of Biological Sciences, Virginia Tech, Blacksburg 24061, VA, USA;Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond 23298, VA, USA;Departments of Neuroscience, Neurobiology Section in the Division of Biological Sciences, University of California, San Diego, La Jolla 92093, CA, USA;Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville 40292, KY, USA

关键词: math5 null;    Dendritic development;    Retinal ganglion cells;    Relay cells;    Retinogeniculate pathway;    Dorsal lateral geniculate nucleus;   

Others  :  1220765
DOI  :  10.1186/s13064-015-0046-6

 received in 2015-01-05, accepted in 2015-07-01,  发布年份 2015

【 摘 要 】

Background

The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been the primary focus, however much less is known about the maturation of their synaptic targets, the relay cells of the dLGN. Here we examined the growth and maturation of relay cells during the first few weeks of life and addressed whether early retinal innervation affects their development. To accomplish this we utilized the math5 null (math5 ^−/− ) mouse, a mutant lacking retinal ganglion cells and central projections.

Results

The absence of retinogeniculate axon innervation led to an overall shrinkage of dLGN and disrupted the pattern of dendritic growth among developing relay cells. 3-D reconstructions of biocytin filled neurons from math5 ^−/− mice showed that in the absence of retinal input relay cells undergo a period of exuberant dendritic growth and branching, followed by branch elimination and an overall attenuation in dendritic field size. However, math5 ^−/− relay cells retained a sufficient degree of complexity and class specificity, as well as their basic membrane properties and spike firing characteristics.

Conclusions

Retinal innervation plays an important trophic role in dLGN development. Additional support perhaps arising from non-retinal innervation and signaling is likely to contribute to the stabilization of their dendritic form and function.

【 授权许可】

   
2015 El-Danaf et al.

【 图 表 】

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