Genetic polymorphisms in lung disease: bandwagon or breakthrough?

Respiratory Research

Benjamin Rybicki¹  Mary Maliarik³  Michael C Iannuzzi² 

[1] Department of Biostatistics and Epidemiology, Henry Ford Health System, Detroit, Michigan, USA;Division of Pulmonary, Critical Care, Henry Ford Health System, Detroit, Michigan, USA;Division of Allergy and Immunology, Henry Ford Health System, Detroit, Michigan, USA

关键词: pulmonary;    polymorphism (genetics);    human;    genetics;    genetic predisposition to disease;   

Others  :  1227405
DOI  :  10.1186/rr164

 received in 2001-08-30, accepted in 2002-01-22,  发布年份 2002

【 摘 要 】

The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to define pathophysiology, to identify persons at risk for pulmonary disease and to predict treatment response. Several pitfalls are commonly encountered in studying genetic polymorphisms, and this article points out criteria that should be applied to design high-quality genetic polymorphism studies.

【 授权许可】

   
2002 BioMed Central Ltd

【 图 表 】

Figure 1.

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