Cross-sectional study on the relationship between the Mediterranean Diet Score and blood lipids

Nutrition Journal

Peter Clarys³  Inge Huybrechts²  Ruben Charlier¹  Johan Lefevre¹  Benedicte Deforche⁴  Patrick Mullie⁵  Evelien Mertens⁴ 

[1]Department of Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Tervuursevest 101, 3001 Leuven, Belgium

[2]International Agency for Research on Cancer (IARC), Dietary Exposure Assessment Group (DEX), 150 Cours Albert Thomas, 69372 Lyon, France

[3]Erasmus University College, Laerbeeklaan 121, 1090 Brussels, Belgium

[4]Department of Human Biometrics and Biomechanics, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium

[5]International Prevention Research Institute (iPRI), 15 chemin du Saquin, Ecully, Lyon, France

关键词: Dietary pattern analysis;    Cardiovascular disease;    Blood cholesterol;    Mediterranean diet score;   

Others  :  1132492
DOI  :  10.1186/1475-2891-13-88

 received in 2014-05-23, accepted in 2014-09-02,  发布年份 2014

【 摘 要 】

Background

Blood lipids are cardiovascular health indicators. High LDL cholesterol values and/or high total cholesterol (TC)/HDL cholesterol ratios are positively related with cardiovascular mortality. Evidence suggests that a Mediterranean diet can reduce the incidence of cardiovascular diseases. Adherence to the Mediterranean diet is often measured by the Mediterranean Diet Score (MDS). However, the association between the Mediterranean diet and blood lipid profiles seems still inconclusive. The aim of this study was to investigate the relationship between the MDS, its different components and blood lipid profiles.

Methods

A sample of 506 women and 707 men (aged 18–75 years) was recruited. Three-day diet records were used to calculate the MDS. Blood samples were analyzed for serum TC, LDL and HDL cholesterol. ANOVA was used to analyze blood lipids across the MDS tertiles. A multivariate linear regression analysis was performed to investigate the associations between the MDS, its components and blood lipids, adjusted for several confounders. All analyses were stratified by gender.

Results

Few gender-specific associations were found between the MDS, its components and blood lipids. Only in men, the total MDS was negatively related with LDL cholesterol and the ratio TC/HDL cholesterol while positively with HDL cholesterol. In women, respectively two (MUFA/SFA and cereals) and in men three (fruits & nuts, meat and alcohol) of the nine MDS components were related with blood lipids.

Conclusions

Analyses investigating the relationship between the MDS, its components and blood lipid profiles indicate only limited influence of the Mediterranean diet on blood lipids. More associations were detected in men compared to women.

【 授权许可】

   
2014 Mertens et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Henríquez Sánchez P, Ruano C, De Irala J, Ruiz-Canela M, Martínez-González MA, Sánchez-Villegas A: Adherence to the Mediterranean diet and quality of life in the SUN Project. Eur J Clin Nutr 2012, 66:360-368.
• [2]Willett WC: The Mediterranean diet: science and practice. Public Health Nutr 2006, 9:105-110.
• [3]Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D: Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 1995, 61:1402S-1406S.
• [4]Keys A, Menotti A, Aravanis C, Blackburn H, Djordevic BS, Buzina R, Dontas AS, Fidanza F, Karvonen MJ, Kimura N: The seven countries study: 2,289 deaths in 15 years. Prev Med 1984, 13:141-154.
• [5]Kromhout D, Bosschieter EB, De Lezenne Coulander C: The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1985, 312:1205-1209.
• [6]Genkinger JM, Koushik A: Meat consumption and cancer risk. PLoS Med 2007, 4:e345.
• [7]Jacques PF, Tucker KL: Are dietary patterns useful for understanding the role of diet in chronic disease? Am J Clin Nutr 2001, 73:1-2.
• [8]Lagiou P, Trichopoulos D, Sandin S, Lagiou A, Mucci L, Wolk A, Weiderpass E, Adami HO: Mediterranean dietary pattern and mortality among young women: a cohort study in Sweden. Br J Nutr 2006, 96:384-392.
• [9]Trichopoulou A, Costacou T, Bamia C, Trichopoulos D: Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003, 348:2599-2608.
• [10]Sofi F, Macchi C, Abbate R, Gensini GF, Casini A: Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr 2013, 1-14.
• [11]Pitsavos C, Panagiotakos DB, Tzima N, Chrysohoou C, Economou M, Zampelas A, Stefanadis C: Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. Am J Clin Nutr 2005, 82:694-699.
• [12]Panagiotakos D, Pitsavos C, Stefanadis C: Dietary patterns: a Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk. Nutr Metab Cardiovasc Dis 2006, 16:559-568.
• [13]Carter SJ, Roberts MB, Salter J, Eaton CB: Relationship between Mediterranean Diet Score and atherothrombotic risk: findings from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994. Atherosclerosis 2010, 210:630-636.
• [14]Yang J, Farioli A, Korre M, Kales SN: Modified mediterranean diet score and cardiovascular risk in a North American working population. PLoS One 2014, 9:e87539.
• [15]De Lorgeril M, Salen P: Dietary prevention of coronary heart disease: the Lyon diet heart study and after. World Rev Nutr Diet 2005, 95:103-114.
• [16]Monda KL, Ballantyne CM, North KE: Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study. J Lipid Res 2009, 50:1685-1691.
• [17]Gostynski M, Gutzwiller F, Kuulasmaa K, Döring A, Ferrario M, Grafnetter D, Pajak A, Project WM: Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA Project. Int J Obes Relat Metab Disord 2004, 28:1082-1090.
• [18]Ki M, Pouliou T, Li L, Power C: Physical (in)activity over 20 y in adulthood: associations with adult lipid levels in the 1958 British birth cohort. Atherosclerosis 2011, 219:361-367.
• [19]Huxley R, Nakamura K, Woodward M: Modification of the effect of lipids on the risk of cardiovascular diseases by cigarette smoking. Clinical Lipidology 2010, 5:413-420.
• [20]Temme E, Huybrechts I, Vandevijvere S, De Henauw S, Leveque A, Kornitzer M, De Backer G, Van Oyen H: Energy and macronutrient intakes in Belgium: results from the first National Food Consumption Survey. Br J Nutr 2010, 103:1823-1829.
• [21]Roos G, Johansson L, Kasmel A, Klumbiene J, Prattala R: Disparities in vegetable and fruit consumption: European cases from the north to the south. Public Health Nutr 2001, 4:35-43.
• [22]Mullie P, Guelinckx I, Clarys P, Degrave E, Hulens M, Vansant G: Cultural, socioeconomic and nutritional determinants of functional food consumption patterns. Eur J Clin Nutr 2009, 63:1290-1296.
• [23]Duvigneaud N, Wijndaele K, Matton L, Deriemaeker P, Philippaerts R, Lefevre J, Thomis M, Duquet W: Socio-economic and lifestyle factors associated with overweight in Flemish adult men and women. BMC Public Health 2007, 7:23. BioMed Central Full Text
• [24]Deriemaeker P, Aerenhouts D, Hebbelinck M, Clarys P: Validation of a 3-day diet diary: comparison with a 7-day diet diary and a FFQ. Med Sci Sports Exerc 2006, 38:S328-S328.
• [25]Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
• [26]Stewart A, Marfell-Jones M, Olds T, De Ridder H: International Society for the Advancement of Kinanthropometry: International Standards for Anthropometric Assessment. Lower Hutt, New Zealand: International Society for the Advancement of Kinanthropometry; 2001.
• [27]Matton L, Wijndaele K, Duvigneaud N, Duquet W, Philippaerts R, Thomis M, Lefevre J: Reliability and validity of the flemish physical activity computerized questionnaire in adults. Res Q Exerc Sport 2007, 78:293-306.
• [28]World Health Organisation: Human energy requirements: report of a joint FAO/ WHO/UNU Expert Consultation. Food Nutr Bull 2005, 26:166.
• [29]ᅟ: The Monica Project of the “Brianza Area”: distribution of coronary risk factors. G Ital Cardiol 1988, 18:1034-1044.
• [30]Kromhout D: Serum cholesterol in cross-cultural perspective: the seven countries study. Acta Cardiol 1999, 54:155-158.
• [31]Fitó M, Guxens M, Corella D, Sáez G, Estruch R, De la Torre R, Francés F, Cabezas C, López-Sabater Me C, Marrugat J, García-Arellano A, Arós F, Ruiz-Gutierrez V, Ros E, Salas-Salvadó J, Fiol M, Solá R, Covas MI: Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Arch Intern Med 2007, 167:1195-1203.
• [32]Rossouw JE: Hormones, genetic factors, and gender differences in cardiovascular disease. Cardiovasc Res 2002, 53:550-557.
• [33]De Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N: Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999, 99:779-785.
• [34]Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, Franco OH, Butterworth AS, Forouhi NG, Thompson SG, Khaw KT, Mozaffarian D, Danesh J, Di Angelantonio E: Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med 2014, 160:398-406.
• [35]De Lorgeril M, Salen P, Paillard F, Laporte F, Boucher F, De Leiris J: Mediterranean diet and the French paradox: two distinct biogeographic concepts for one consolidated scientific theory on the role of nutrition in coronary heart disease. Cardiovasc Res 2002, 54:503-515.
• [36]De Lorgeril M: Mediterranean diet and cardiovascular disease: historical perspective and latest evidence. Curr Atheroscler Rep 2013, 15:370.
• [37]Kris-Etherton P, Eckel RH, Howard BV, St Jeor S, Bazzarre TL, Association NCPSCaCSCotAH: AHA science advisory: Lyon Diet Heart Study: benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. Circulation 2001, 103:1823-1825.
• [38]Dai J, Jones D, Goldberg J, Ziegler T, Bostick R, Wilson P, Manatunga A, Shallenberger L, Jones L, Vaccarino V: Association between adherence to the Mediterranean diet and oxidative stress. Am J Clin Nutr 2008, 88:1364-1370.
• [39]Schwingshackl L, Hoffmann G: Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials. Nutr Metab Cardiovasc Dis 2014, 39:929-939.
• [40]Nadtochiy SM, Redman EK: Mediterranean diet and cardioprotection: the role of nitrite, polyunsaturated fatty acids, and polyphenols. Nutrition 2011, 27:733-744.
• [41]Torng PL, Su TC, Sung FC, Chien KL, Huang SC, Chow SN, Lee YT: Effects of menopause on intraindividual changes in serum lipids, blood pressure, and body weight–the Chin-Shan Community Cardiovascular Cohort study. Atherosclerosis 2002, 161:409-415.
• [42]Forey BA, Fry JS, Lee PN, Thornton AJ, Coombs KJ: The effect of quitting smoking on HDL-cholesterol - a review based on within-subject changes. Biomark Res 2013, 1:26. BioMed Central Full Text
• [43]Von Elm E, Röllin A, Blümle A, Huwiler K, Witschi M, Egger M: Publication and non-publication of clinical trials: longitudinal study of applications submitted to a research ethics committee. Swiss Med Wkly 2008, 138:197-203.
• [44]Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR, Bangdiwala S, Tyroler HA: High-density lipoprotein cholesterol and cardiovascular disease: four prospective American studies. Circulation 1989, 79:8-15.