Cervical adenoid basal carcinoma associated with invasive squamous cell carcinoma: A report of rare co-existence and review of literature

World Journal of Surgical Oncology

Soo Young Hur²  Min Jong Song²  Chung Won Lee²  Jong Sup Park²  Ah Won Lee¹  Sung Taek Park²  Boonlert Viriyapak² 

[1] Department of Pathology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea;Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea

关键词: Cervix Uteri;    Carcinoma;    Squamous Cell;    Adenoid Basal;   

Others  :  1206632
DOI  :  10.1186/1477-7819-9-132

 received in 2011-06-20, accepted in 2011-10-18,  发布年份 2011

【 摘 要 】

Cervical adenoid basal carcinoma (ABC) rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC), which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor of radical surgery for the primary treatment of suspicious associated malignancy, and supports adjuvant treatment according to the unfavorable extent of the co-existent invasive carcinoma.

【 授权许可】

   
2011 Viriyapak et al; licensee BioMed Central Ltd.

【 图 表 】

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