Surgical outcomes in patients with small cell lung cancer: comparative analysis of computed tomograpy-detected patients with others

World Journal of Surgical Oncology

Nobuhiro Nishizawa²  Ryouhei Yamamoto²  Ryoichi Kondo¹  Kazuo Yoshida³  Takayuki Shiina³  Kazutoshi Hamanaka³  Toshirou Fukushima³  Tomonobu Koizumi⁴ 

[1] Division of Thoracic Surgery, Chushin Matsumoto Hospital, 811 Kotobuki Toyooka, Matsumoto city, 399-0021, Japan;Division of Thoracic Surgery, Saku Central Hospital, 197 Usuda, Saku, 384-0301, Japan;Respiratory Center Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto city, 390-8621, Japan;Comprehensive Cancer Therapy, Division of Clinical Oncology, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto Nagano, Matsumoto city 390-8621, Japan

关键词: Early stage;    LD-SCLC;    Survey;    Surgery;    Chemotherapy;    Small cell lung cancer;   

Others  :  825951
DOI  :  10.1186/1477-7819-11-61

 received in 2012-10-15, accepted in 2013-02-23,  发布年份 2013

【 摘 要 】

Background

It is shown that low-dose computed tomography (CT) screening is useful for a reduction in lung-cancer-specific mortality in heavy smokers. However, the information about effectiveness according to the histological types of lung cancer has not been adequately investigated especially small cell lung cancer (SCLC). The present study was performed to see the clinical benefit of CT screening in patients with SCLC following thoracotomy.

Methods

We retrospectively reviewed the outcome in patients with early stage SCLC who initially underwent thoracotomy. The clinical stages and actuarial survival were estimated according to the three means of detection of SCLC: chest CT, radiographic screen, and symptomatically prompted cases.

Results

Sixty-nine patients (men/women, 63/6; mean age, 70 years) with SCLC underwent thoracotomy between 1991 and 2010 including chest CT (n = 13), radiographic screening (n = 39), and symptomatically prompted cases (n = 17). Pathological staging information included stage IA (n = 25), IB (n = 8), IIA (n = 13), IIB (n = 5), IIIA (n = 11), and IIIB (n = 7). Median survival time was 30.0 (95% confidence interval (CI): 22.0 to 57.0) months, with overall survival at 5 years of 34.3% (95% CI, 23.47 to 47.3). Nine patients (69%) with stage I were detected by CT which was significantly higher than those in other detection arms. However, there were no significant differences in the survival between CT and other detection arms.

Conclusions

CT examination may be useful for detection in early stage SCLC potentially suitable for surgery, but the contribution to better clinical outcome in patients with SCLC remains unclear.

【 授权许可】

   
2013 Koizumi et al; licensee BioMed Central Ltd.

【 图 表 】

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