The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study

Respiratory Research

Joan M Cook-Mills²  Kiang Liu⁵  Akshay Sood¹  Myron Gross⁴  David R Jacobs⁶  Pedro C Avila²  Laura A Colangelo⁵  Rajesh Kumar³  Michelle E Marchese² 

[1] Division of Pulmonary and Critical Care Medicine, University of New Mexico, Albuquerque, NM 87131, USA;Division of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, McGaw M304, 240 E. Huron, Chicago, IL, 60611, USA;The Ann and Robert H. Lurie Children’s Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA;Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;Department of Nutrition, School of Medicine, University of Oslo, Oslo, Norway

关键词: Human;    FVC;    FEV₁;    γ-tocopherol;    α-tocopherol;   

Others  :  790371
DOI  :  10.1186/1465-9921-15-31

 received in 2013-10-09, accepted in 2014-02-26,  发布年份 2014

【 摘 要 】

Background

Clinical studies of the associations of vitamin E with lung function have reported conflicting results. However, these reports primarily examine the α-tocopherol isoform of vitamin E and have not included the isoform γ-tocopherol which we recently demonstrated in vitro opposes the function of α-tocopherol. We previously demonstrated, in vitro and in animal studies, that the vitamin E isoform α-tocopherol protects, but the isoform γ-tocopherol promotes lung inflammation and airway hyperresponsiveness.

Methods

To translate these findings to humans, we conducted analysis of 4526 adults in the Coronary Artery Risk Development in Young Adults (CARDIA) multi-center cohort with available spirometry and tocopherol data in blacks and whites. Spirometry was obtained at years 0, 5, 10, and 20 and serum tocopherol was from years 0, 7 and 15 of CARDIA.

Results

In cross-sectional regression analysis at year 0, higher γ-tocopherol associated with lower FEV₁ (p = 0.03 in blacks and p = 0.01 in all participants) and FVC (p = 0.01 in blacks, p = 0.05 in whites, and p = 0.005 in all participants), whereas higher α-tocopherol associated with higher FVC (p = 0.04 in blacks and whites and p = 0.01 in all participants). In the lowest quartile of α-tocopherol, higher γ-tocopherol associated with a lower FEV₁ (p = 0.05 in blacks and p = 0.02 in all participants). In contrast, in the lowest quartile of γ-tocopherol, higher α-tocopherol associated with a higher FEV₁ (p = 0.03) in blacks. Serum γ-tocopherol >10 μM was associated with a 175–545 ml lower FEV₁ and FVC at ages 21–55 years.

Conclusion

Increasing serum concentrations of γ-tocopherol were associated with lower FEV1 or FVC, whereas increasing serum concentrations of α-tocopherol was associated with higher FEV1 or FVC. Based on the prevalence of serum γ-tocopherol >10 μM in adults in CARDIA and the adult U.S. population in the 2011 census, we expect that the lower FEV₁ and FVC at these concentrations of serum γ-tocopherol occur in up to 4.5 million adults in the population.

【 授权许可】

   
2014 Marchese et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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