Multiscale perspectives of virus entry via endocytosis

Virology Journal

Jin Liu²  Anthony V Nicola¹  Eric Barrow² 

[1] Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164, USA;School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA

关键词: Multiscale modeling;    Virus trafficking;    Multiple scales;    Endocytosis;    Theoretical modeling;    Viral entry;   

Others  :  1149899
DOI  :  10.1186/1743-422X-10-177

 received in 2013-04-24, accepted in 2013-05-24,  发布年份 2013

【 摘 要 】

Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strategies. Virus entry via endocytosis is a complex process involving hundreds of cellular proteins. The entire process is dictated by events occurring at multiple time and length scales. In this review, we discuss and evaluate the available means to investigate virus endocytic entry, from both experimental and theoretical/numerical modeling fronts, and highlight the importance of multiscale features. The complexity of the process requires investigations at a systems biology level, which involves the combination of different experimental approaches, the collaboration of experimentalists and theorists across different disciplines, and the development of novel multiscale models.

【 授权许可】

   
2013 Barrow et al.; licensee BioMed Central Ltd.

【 图 表 】

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