Active hepatitis C infection and HCV genotypes prevalent among the IDUs of Khyber Pakhtunkhwa

Virology Journal

Anila Tariq Jahangiri²  Zahoor Ahmed Swati²  Najib ullah Khan²  Khaleeq Uz Zaman²  Sher Hayat Khan⁴  Sanaullah Khan¹  Aqib Iqbal²  Imtiaz Ali Khan³  Ijaz Ali²  Ihasn Ullah²  Latif ur Rehman² 

[1] Kohat University of Science and Technology, Kohat, Pakistan;Institute of Biotechnology and Genetic Engineering, KPK Agricultural University, Peshawar, Pakistan;Department of Entomology, KPK-Agricultural University, Peshawar, Pakistan;Department of Animal Health, KPK-Agricultural University, Peshawar, Pakistan

关键词: KPK;    RT-PCR;    Genotype;    HCV;    IDUs;   

Others  :  1156489
DOI  :  10.1186/1743-422X-8-327

 received in 2011-03-26, accepted in 2011-06-28,  发布年份 2011

【 摘 要 】

Injection drug users (IDUs) are considered as a high risk group to develop hepatitis C due to needle sharing. In this study we have examined 200 injection drug users from various regions of the Khyber Pakhtunkhwa province for the prevalence of active HCV infection and HCV genotypes by Immunochromatographic assays, RT-PCR and Type-specific PCR. Our results indicated that 24% of the IDUs were actively infected with HCV while anti HCV was detected among 31.5% cases. Prevalent HCV genotypes were HCV 2a, 3a, 4 and 1a. Majority of the IDUs were married and had attained primary or middle school education. 95% of the IDUs had a previous history of needle sharing. Our study indicates that the rate of active HCV infection among the IDUs is higher with comparatively more prevalence of the rarely found HCV types in KPK. The predominant mode of HCV transmission turned out to be needle sharing among the IDUs.

【 授权许可】

   
2011 ur Rehman et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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