Mechanical ventilation: lessons from the ARDSNet trial

Respiratory Research

V Marco Ranieri¹  Arthur S Slutsky² 

[1] Ospedale Sanata Chiara, Università di Pisa, Pisa, Italy;St Michael's Hospital, University of Toronto, Toronto, Canada

关键词: respiratory failure;    iatrogenic;    biotrauma;    barotrauma;    artificial respiration;    acute lung injury;   

Others  :  1227485
DOI  :  10.1186/rr15

 received in 2000-07-17, accepted in 2000-08-18,  发布年份 2000

【 摘 要 】

The acute respiratory distress syndrome (ARDS) is an inflammatory disease of the lungs characterized clinically by bilateral pulmonary infiltrates, decreased pulmonary compliance and hypoxemia. Although supportive care for ARDS seems to have improved over the past few decades, few studies have shown that any treatment can decrease mortality for this deadly syndrome. In the 4 May 2000 issue of New England Journal of Medicine, the results of an NIH-sponsored trial were presented; they demonstrated that the use of a ventilatory strategy that minimizes ventilator-induced lung injury leads to a 22% decrease in mortality. The implications of this study with respect to clinical practice, further ARDS studies and clinical research in the critical care setting are discussed.

【 授权许可】

   
2000 Current Science Ltd

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