Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever

Virology Journal

Cecilia Dayaraj¹  Paresh S Shah²  Asha B Bhagat²  Rupali V Bachal²  Kalichamy Alagarasu² 

[1] National Institute of Virology, 20-A, Ambedkar road, Pune 411001, Maharashtra, India;Dengue group, National Institute of Virology, 20-A, Ambedkar road, Pune, Maharashtra, India

关键词: DHF;    DF;    Mannose binding lectin;    Vitamin D;    Dengue;   

Others  :  1154760
DOI  :  10.1186/1743-422X-9-86

 received in 2011-09-20, accepted in 2012-05-04,  发布年份 2012

【 摘 要 】

Background

Altered plasma concentrations of vitamin D and mannose binding lectin (MBL), components of innate immunity, have been shown to be associated with the pathogenesis of viral infections. The objective of the present study was to find out whether plasma concentrations of MBL and vitamin D are different in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF).

The results

The plasma concentrations of vitamin D and MBL were assessed in 48 DF cases, 45 DHF cases and 20 apparently healthy controls using ELISA based methods. Vitamin D concentrations were found to be higher among both DF and DHF cases as compared to healthy controls (P < 0.005 and P < 0.001). Vitamin D concentrations were not different between DF and DHF cases. When the dengue cases were classified into primary and secondary infections, secondary DHF cases had significantly higher concentrations of vitamin D as compared to secondary DF cases (P < 0.050). MBL concentrations were not significantly different between healthy controls and dengue cases. MBL concentrations were observed to be lower in DHF cases as compared to DF cases (P < 0.050). Although MBL levels were not different DF and DHF cases based on immune status, the percentage of primary DHF cases (50%) having MBL levels lower than 500 ng/ml were less compared to primary DF cases (P = 0.038).

Conclusions

The present study suggests that higher concentrations of vitamin D might be associated with secondary DHF while deficiency of MBL may be associated with primary DHF.

【 授权许可】

   
2012 Alagarasu et al.; licensee BioMed Central Ltd.

【 图 表 】

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