Transmission of H7N9 influenza virus in mice by different infective routes

Virology Journal

Chuan Qin²  Honglin Chen¹  Pin Yu²  Yanfeng Yao²  Jiangning Liu²  Yanhong Li²  Lan Huang²  Yanfeng Xu²  Jing Yuan²  Fengdi Li²  Qi Lv²  Ting Chen²  Wei Deng²  Hua Zhu²  Lili Xu²  Linlin Bao² 

[1] Department of Microbiology and the Research Center of Infection and Immunology, State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China;Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical Collage (PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, No. 5 Pan Jia Yuan Nan Li, Beijing 100021, Chaoyang District, China

关键词: Pharyngeal secretions;    Feces;    Ocular secretions;    Route of transmission;    Direct contact;    H7N9 influenza virus;   

Others  :  1131246
DOI  :  10.1186/1743-422X-11-185

 received in 2013-12-05, accepted in 2014-10-03,  发布年份 2014

【 摘 要 】

Background

On 19 February 2013, the first patient infected with a novel influenza A H7N9 virus from an avian source showed symptoms of sickness. More than 349 laboratory-confirmed cases and 109 deaths have been reported in mainland China since then. Laboratory-confirmed, human-to-human H7N9 virus transmission has not been documented between individuals having close contact; however, this transmission route could not be excluded for three families. To control the spread of the avian influenza H7N9 virus, we must better understand its pathogenesis, transmissibility, and transmission routes in mammals. Studies have shown that this particular virus is transmitted by aerosols among ferrets.

Methods

To study potential transmission routes in animals with direct or close contact to other animals, we investigated these factors in a murine model.

Results

Viable H7N9 avian influenza virus was detected in the upper and lower respiratory tracts, intestine, and brain of model mice. The virus was transmissible between mice in close contact, with a higher concentration of virus found in pharyngeal and ocular secretions, and feces. All these biological materials were contagious for naïve mice.

Conclusions

Our results suggest that the possible transmission routes for the H7N9 influenza virus were through mucosal secretions and feces.

【 授权许可】

   
2014 Bao et al.; licensee BioMed Central Ltd.

【 图 表 】

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