期刊论文详细信息
Radiation Oncology
Neurosymptomatic carvenous sinus meningioma: a 15-years experience with fractionated stereotactic radiotherapy and radiosurgery
Manoel Jacobsen Teixeira3  Gustavo Nader Marta2  Sebastião Francisco Miranda Correa1 
[1] Radiation Oncology Department - Hospital Sírio-Libanês, Rua Dona Adma Jafet, 91 - Bela Vista, CEP 01308-050 Sao Paulo, SP, Brazil;Radiation Oncology Department Instituto do Câncer do Estado de São Paulo (ICESP), Sao Paulo, Brazil;Department of Neurology at the Medical School, University of São Paulo, São Paulo, SP, Brazil
关键词: Radiotherapy;    Fractionated stereotactic;    Radiosurgery;    Radiotherapy;    Meningioma;   
Others  :  814987
DOI  :  10.1186/1748-717X-9-27
 received in 2013-05-31, accepted in 2014-01-09,  发布年份 2014
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【 摘 要 】

Background

The tumor removal of Cavernous Sinus Meningiomas usually results in severe neurological deficits. Stereotactic radiosurgery (SRS) and fractionated Stereotactic radiotherapy (SRT) are advanced modalities of radiotherapy for treatment of patients with inoperable and symptomatic CSMs. The authors evaluated the long term symptomatology, the image findings, and the toxicity of patients with CSMs treated with SRS or SRT.

Patients and methods

From 1994 to 2009, 89 patients with symptomatic CSMs were treated with SRS or SRT. The indication was based on tumour volume and or proximity to the optic chiasm. The median single dose of SRS was 14 Gy, while the SRT total dose, ranged from 50.4 to 54 Gy fractionated in 1.8-2 Gy/dose. The median follow-up period lasted 73 months.

Results

The clinical and radiological improvement was the same despite the method of radiotherapy; 41.6% (SRS) and 48.3% (SRT) of patients treated. The disease-free survivals were 98.8%, 92.3% and 92.3%, in 5, 10, and 15 years, respectively. There was no statistical difference in relation to the symptoms and image findings between both methods. According to the Common Toxicity Criteria, 7% of the patients presented transient optic neuropathy during 3 months (grade 2) and recovered with dexamethasone, 2 patients had trigeminal neuropathy (grade 2) and improved rapidly, and one patient presented total occlusion of the internal carotid artery without neurological deficit (grade 2). Temporary lethargy and headache (grade 1) were the most frequent immediate complications. No severe complications occurred.

Conclusions

Stereotactic Radiosurgery and fractionated Stereotactic Radiotherapy were equally safe and effective in the management of symptomatic CSMs.

【 授权许可】

   
2014 Correa et al.; licensee BioMed Central Ltd.

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