Tumor necrosis factor-α and muscle wasting: a cellular perspective

Respiratory Research

Yi-Ping Li¹  Michael B Reid¹ 

[1] Pulmonary Section, Baylor College of Medicine, Houston Texas, USA

关键词: skeletal muscle;    free radicals;    cytokines;    cachexia;    antioxidants;   

Others  :  1227436
DOI  :  10.1186/rr67

 received in 2001-04-30, accepted in 2001-06-12,  发布年份 2001

【 摘 要 】

Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-α on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-α disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-κB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-α effects on skeletal muscle and the mechanism of TNF-α action.

【 授权许可】

   
2001 BioMed Central Ltd

【 图 表 】

Figure 1.

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