Total dietary fat and omega-3 fatty acids have modest effects on urinary sex hormones in postmenopausal women

Nutrition & Metabolism

Mindy S Kurzer²  J Bruce Redmon³  William Thomas¹  Susan K Raatz⁴  Lindsay R Young² 

[1] Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA;Department of Food Science and Nutrition, University of Minnesota, Minneapolis, MN, USA;Department of Medicine, University of Minnesota, Minneapolis, MN, USA;USDA Grand Forks Human Nutrition Research Center, 2420 2nd Ave N, Grand Forks, ND, 58203, USA

关键词: Postmenopausal women;    Urinary estrogens;    Low fat diet;    Omega-3 fatty acids;    Dietary fat;   

Others  :  804497
DOI  :  10.1186/1743-7075-10-36

 received in 2013-01-07, accepted in 2013-04-07,  发布年份 2013

【 摘 要 】

Background

Total fat and omega-3 fatty acids in the diet may affect breast cancer risk by altering estrogen metabolism. The purpose of this study was to elucidate the effects of differing total fat and omega-3 fatty acid content of diets on a panel of urinary estrogens and metabolites.

Findings

A controlled, cross-over feeding trial was conducted in postmenopausal women using three test diets: high fat diet (HF; 40% energy from fat), low fat diet (LF; 20% of energy from fat) and low fat, high omega-3 diet (LFn3; 23% energy from fat; 3% omega-3 fatty acids) for 8 week periods. Urinary hormone concentrations for 16 women were compared among diets using a linear mixed model, and within diet comparisons were made using paired t-tests. Urinary excretion of estrone was greater after the LF and LFn3 compared to the HF (P = 0.004). Estrone excretion was increased from baseline within the LF only (P = 0.02). Total estrone + estradiol + estriol increased from baseline with LF (P = 0.02) and was greater than the other two diets at 8 weeks (P = 0.03). There were no effects on estrogen metabolites, including the 2-hydroxy estrone:16α-hydroxy estrone ratio.

Conclusions

The results of this study indicate that urinary sex hormone metabolism was modestly altered in postmenopausal women by a low fat dietary intervention.

【 授权许可】

   
2013 Young et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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