Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection

Retrovirology

Nilu Goonetilleke⁵  Feng Gao²  Andrew J McMichael³  Bette T Korber¹  Salim S Abdool Karim⁶  Simon Brackenridge³  Hongshuo Song⁷  Sheri Chen⁷  Nicola MG Smith³  Fangping Cai⁷  Adam John Ritchie⁴ 

[1] The Sante Fe Institute, Sante Fe 87501, NM, USA;National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, Jilin, China;Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK;Blavatnik School of Government, University of Oxford, Oxford OX1 4JJ, UK;Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill 27599, NC, USA;University of KwaZulu-Natal, Durban 4041, South Africa;Department of Medicine, Duke University, Durham 27710, NC, USA

关键词: Acute infection;    Immunodominance;    Recombination;    Multiple infection;    T cell;    HIV-1;   

Others  :  1152480
DOI  :  10.1186/s12977-014-0069-9

 received in 2013-12-13, accepted in 2014-07-31,  发布年份 2014

【 摘 要 】

Background

A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.

Results

Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.

Conclusions

Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.

【 授权许可】

   
2014 Ritchie et al.; licensee BioMed Central Ltd.

【 图 表 】

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