The effect of the macrobiotic Ma-Pi 2 diet vs. the recommended diet in the management of type 2 diabetes: the randomized controlled MADIAB trial

Nutrition & Metabolism

for the MADIAB Group³  Paolo Pozzilli³  Mario Pianesi²  Francesco Fallucca⁴  Silvia Manfrini³  Rosaria Gesuita⁵  Edlira Skrami⁵  Carmen Porrata¹  Vladimir Ruiz⁶  Francesca Capata³  Valeria Formisano³  Silvia Angeletti⁸  Sara Fallucca³  Lucia Fontana⁷  Elena Roncella³  Rossella Del Toro³  Yeganeh M Khazrai³  Andreea Soare³ 

[1] Clinical Assay Direction, Finlay Institute, Avenue 27, No. 19805, La Coronela, La Lisa 11600, Havana, Cuba;International Study Center for Environment, Agriculture, Food, Health and Economics, Via San Nicola, 62029 Rome, Italy;Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo 21, 00128 Rome, Italy;Department of Clinical Sciences, La Sapienza University II Faculty, Via di Grottarossa 1035/1039, 00189 Rome, Italy;Center of Epidemiology, Biostatistics and Medical Information Technology, Polytechnic Marche University, Via Tronto 10A, 60020 Ancona, Italy;Department of Biochemistry and Physiology, Institute of Nutrition and Food Hygiene, Infanta 1158, 10300 Havana, Cuba;Unit of Dietology and Diabetology, Sandro Pertini Hospital, Via dei Monti Tiburtini 385, 00157 Rome, Italy;Department of Laboratory Medicine, University Campus Bio-Medico, Rome, Italy

关键词: Type 2 diabetes;    Macrobiotic diet;    Fasting blood glucose;   

Others  :  1131720
DOI  :  10.1186/1743-7075-11-39

 received in 2014-04-19, accepted in 2014-08-17,  发布年份 2014

【 摘 要 】

Background

Diet is an important component of type 2 diabetes therapy. Low adherence to current therapeutic diets points out to the need for alternative dietary approaches. This study evaluated the effect of a different dietary approach, the macrobiotic Ma-Pi 2 diet, and compared it with standard diets recommended for patients with type 2 diabetes.

Methods

A randomized, controlled, open-label, 21-day trial was undertaken in patients with type 2 diabetes comparing the Ma-Pi 2 diet with standard (control) diet recommended by professional societies for treatment of type 2 diabetes. Changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) were primary outcomes. HbA_1c, insulin resistance (IR), lipid panel and anthropometrics were secondary outcomes.

Results

After correcting for age, gender, BMI at baseline, and physical activity, there was a significantly greater reduction in the primary outcomes FBG (95% CI: 1.79; 13.46) and PPBG (95% CI: 5.39; 31.44) in those patients receiving the Ma-Pi 2 diet compared with those receiving the control diet. Statistically significantly greater reductions in the secondary outcomes, HbA_1c (95% CI: 1.28; 5.46), insulin resistance, total cholesterol, LDL cholesterol and LDL/HDL ratio, BMI, body weight, waist and hip circumference were also found in the Ma-Pi 2 diet group compared with the control diet group. The latter group had a significantly greater reduction of triglycerides compared with the Ma-Pi 2 diet group.

Conclusions

Intervention with a short-term Ma-Pi 2 diet resulted in significantly greater improvements in metabolic control in patients with type 2 diabetes compared with intervention with standard diets recommended for these patients.

Trial registration

Current Controlled Trials ISRCTN10467793.

【 授权许可】

   
2014 Soare et al.; licensee BioMed Central Ltd.

【 图 表 】

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