Antioxidant intake among Brazilian adults - The Brazilian Osteoporosis Study (BRAZOS): a cross-sectional study

Nutrition Journal

Marcos Bosi Ferraz¹  Patrícia de Souza Genaro³  Claudia Ridel Juzwiak⁴  Luana Aquino²  Gabriela Villaça Chaves²  Rozana Mesquita Ciconelli¹  Marcelo Medeiros Pinheiro⁵ 

[1] Paulista Center for Health Economics, Unifesp/ EPM, Brazil;Micronutrient Research Center, Josué de Castro Nutrition Institute, Universidade Federal do Rio de Janeiro, Brazil;Rheumatology Division, Federal University of Sao Paulo, Unifesp/ EPM, Brazil;Department of Health, Education and Society, Nutrition Course, Unifesp/Baixada Santista Campus, Brazil;Rheumatology Division, Federal University of Sao Paulo/ Paulista School of Medicine (Unifesp/ EPM), Brazil

关键词: Public Health;    Brazilian population;    antioxidant;    micronutrients;    dietary recall;    nutritional intake;   

Others  :  840286
DOI  :  10.1186/1475-2891-10-39

 received in 2010-10-29, accepted in 2011-04-25,  发布年份 2011

【 摘 要 】

Background

Antioxidant nutrient intake and the lesser formation of free radicals seem to contribute to chronic diseases. The aim of the present study was to evaluate the intake profile of the main dietary antioxidants in a representative sample of the adult Brazilian population and discuss the main consequences of a low intake of these micronutrients on overall health.

Methods

The sample comprised 2344 individuals aged 40 years or older from 150 cities and was based on a probabilistic sample from official data. The research was conducted through in-home interviews administered by a team trained for this purpose. Dietary intake information was obtained through 24-h recall. The Nutrition Data System for Research software program was used to analyze data on the intake of vitamins A, C and E, selenium and zinc, which was compared to Dietary Reference Intakes (DRIs). Differences in intake according to sex, anthropometrics, socioeconomic status and region were also evaluated. The SPSS statistical package (version 13) was used for the statistical analysis. P-values < 0.05 were considered significant.

Results

Higher proportions of low intake in relation to recommended values were found for vitamin E (99.7%), vitamin A (92.4%) and vitamin C (85.1%) in both genders. Intake variations were found between different regions, which may reflect cultural habits.

Conclusion

These results should lead to the development of public health policies that encourage educational strategies for improving the intake of micronutrients, which are essential to overall health and prevention of non-communicable diseases.

【 授权许可】

   
2011 de Medeiros Pinheiro et al; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Instituto Brasileiro de Geografia e Estatística [http://www.ibge.gov.br/home/estatistica/populacao/censo2000/default.shtm] webcite 2000.
• [2]Instituto Brasileiro de Geografia e Estatística: Pesquisa de orçamentos familiares 2002-2003: Análise da disponibilidade domiciliar de alimentos e do estado nutricional no Brasil. Rio de Janeiro: Ministério do Planejamento e Orçamento/IBGE; 2004.
• [3]Shetty P, Shimidhuber J: Introductory lecture the epidemiology and determinants of obesity in developed and developing countries. Int J Vitam Nutr Res 2006, 4:157-62.
• [4][WHO]. World Health Organization: The world report 2002: reducing risks, promoting healthy life. Geneve: World Health Organization; 2002.
• [5][WHO] World Health Organization: Prevention of cardiovascular disease: pocket guidelines for assessment and management of cardiovascular risk. Geneve; 2007.
• [6]Riccioni G, Bucciarelli T, Mancini B, Corradi F, Di Ilio C, Mattei PA, D'Orazio N: Antioxidant vitamin supplementation in cardiovascular diseases. Ann Clin Lab Sci 2007, 37:89-95.
• [7]Department of Health and Human Services: National Center for Health Statistics. Healthy people 2000: national health promotion and disease prevention objectives. Washington; 1991.
• [8][IOM] Institute of Medicine: Dietary Reference Intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, panthotenic acid. Washington, D.C.: National Academy Press; 1998.
• [9][IOM] Institute of Medicine: Dietary reference intakes. Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, D.C.: National Academy Press; 2000.
• [10][IOM] Institute of Medicine: Dietary reference intakes. Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, D.C.: National Academy Press; 2001.
• [11]Després JP, Pascot A, Lemieux I: Risk factors associated with obesity: a metabolic perspective. Ann Endocrinol 2000, 61(Suppl 6):31-38.
• [12]Schaefer EJ: Lipoproteins, nutrition, and heart disease. Am J Clin Nutr 2002, 75:191-212.
• [13]Halliwell B, Aeschbach R, Löliger J, Aruoma OI: The characterization of antioxidants. Food Chem Toxicol 1995, 33:601-17.
• [14]Berger MM: Can oxidative damage be treated nutritionally? Clin Nutr 2005, 24:172-83.
• [15]Clark SF: The biochemistry of antioxidants revisited. Nutr Clin Pract 2002, 17:5-17.
• [16]Jones DP: Redefining oxidative stress. Antioxid Redox Signal 2006, 8(9-10):1865-79.
• [17]Sies H: Biological redox systems and oxidative stress. Cell Mol Life Sci 2007, 64(17):2181-8.
• [18]Czernichow S, Hercberg S: Interventional studies concerning the role of antioxidants vitamins in cardiovascular diseases; a review. J Nutrition Health & Aging 2001, 5:188-195.
• [19]Rissamen TH, Voutilainem S, Nyyssonen K, Salonen R, Kaplan GA, Salonen JT: Serun lycone concentrations and carotid atherosclerosis: the Kuopio ischaemic heart disease risk factor study. Am J Clin Nutr 2003, 77:133-38.
• [20]Sesso HD, Buring JE, Norkus EP, Gaziano JM: Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am J Clin Nutr 2004, 79:47-53.
• [21]National Home Sampling Survey (PNAD) [http:/ / www.ibge.gov.br/ home/ estatistica/ populacao/ trabalhoererendimento/ pnad2003/ coeficiente_brasil.shtm] webcite 2003.
• [22]Pinheiro MM, Scuch NJ, Genaro PS, Ciconelli RM, Ferraz MB, Martini LA: Nutrient intakes related to osteoporotic fractures in men and women - The Brazilian Osteoporosis Study (BRAZOS). Nutr J 2009, 8:6. BioMed Central Full Text
• [23][WHO] World Health Organization: Obesity: preventing and managing the global epidemic. Report of WHO consultation on obesity. World health organization, Geneva; 1998.
• [24]Nutrition Coordinating Center (NCC), University of Minnesota: Nutrition Data System for Research-NDS-R [programa de computador]. University of Minnesota: Minneapolis; 2005.
• [25]Pinheiro MM, Ciconelli RM, Martini LA, Ferraz MB: Clinical risk factors for osteoporotic fractures in Brazilian women and men: The Brazilian Osteoporosis Study (BRAZOS). Osteoporos Int 2009, 20:399-408.
• [26]Willett W, Stampfer M: Implications of total energy intake for epidemiological analyses. In Nutritional epidemiology. 2nd edition. Edited by Willett W. New York: Oxford University Press; 1998:273-301.
• [27]Campos MTFS, Monteiro JBR, Ornelas APRC: Fatores que afetam o consumo alimentar e a Nutrição do idoso. Rev Nutr Campinas 2000, 13:157-165.
• [28]Lebrão ML, Laurenti R: Saúde, bem-estar e envelhecimento: o estudo SABE no municipio de São Paulo. Rev Bras Epidemiol 2005, 8:127-41.
• [29]Beckman KB, Ames BN: The free radical theory of aging matures. Physiol Rev 1998, 78:547-81.
• [30]Chernoff R: Micronutrients requirements in older women. Am J Clin Nutr 2005, 81(suppl):1240S-5S.
• [31]Ancona-Lopez F, Juzwiak CR: Social impact of modern diet and tendencies. In Food, diet, health: past, present and future tendencies. Edited by Guiné RP. Hanppange, New York: Nova Science Publishers; 2010.
• [32]Young LR, Nestle M: The contribution of expanding portion sizes to the US obesity epidemic. Am J Public Health 2002, 92:246-9.
• [33]Fernandes M, Paes C, Nogueira C, Souza G, Aquino L, Borges F, Ramalho A: Perfil de consumo de nutrientes antioxidantes em pacientes com síndrome metabólica. Rev Ciênc Méd 2007, 16:209-19.
• [34]Neumann AI, Martins IS, Marcopito LF, Araujo EA: Dietary patterns associated with risk factors for cardiovascular disease in a Brazilian city. Rev Panam Salud Publica 2007, 22:329-39.
• [35]Neuhouser ML, Rock CL, Eldridge AL, et al.: Serum concentrations of retinol, alfa-tocoferol and carotenoids are influenced by diet, race and obesity in a sample of health adolescents. J Nutr 2001, 131:2184-219.
• [36]Sarni RS, Kochi C, et al.: Vitamin A: blood level and dietetics intake in stunted children and adolescents without hormonal disease. Rev Assoc Med Bras 2002, 48:48-53.
• [37]Sarni RS, Kochi C, et al.: Impact of vitamin A megadose supplementation on the anthropometry of children and adolescents with non-hormonal statural deficit: a double-blind and randomized clinical study. Int J Vitam Nutr Res 2003, 73:303-11.
• [38]Silva LSVL, Veiga GVV, Ramalho RA: Association of serum concentrations of retinol and carotenoids with overweight in children and adolescents. Nutrition 2007, 23:392-97.
• [39]Matsuoka H: Endothelial dysfunction associated with oxidative stress in human. Diab Res Clin Pract 2001, 54:65-72.
• [40]Jeyakumar SM, Vajerswaria A, Giridharan NV: Chronic dietary vitamin A supplementation regulates obesity: in obese mutant rat model of WNIN/Ob strain. Obesity research. J Mol Endocrinol 2006, 35:391-98.
• [41]Ochoa JJ, Vilchez MJ, Mataix J, Ibáñez-Quiles S, Palacios MA, Muñoz-Hoyos A: Oxidative stress in patients undergoing cardiac surgery: comparative study of revascularization and valve replacement procedures. J Surg Res 2003, 111:248-54.
• [42]Delport R: Antioxidants and coronary artery disease risk in South African males. Clinical Chimical Acta 1998, 278:55-60.
• [43]Lopes ACS, Caiaffa WT, Sichieri R, Mingoti SA, Lima-Costa MF: Consumo de nutrientes em adultos e idosos em estudo de base populacional: Projeto Bambuí. Cad Saúde Pública 2005, 21:1201-09.
• [44]Fietz VR: Estado nutricional, consumo de alimentos e condições socioeconômicas das famílias de assentamento rural em Mato Grosso do Sul. PhD thesis. Faculdade de Engenharia de Alimentos. Universidade de Campinas; 2007.
• [45]Ramalho RA, Flores H, Accioly E, Saunders C: Vitamin A Deficiency in Brasil. Revista da Sociedad Iberoamericana de Información Científica 2005, 1:1-9.
• [46]Ramalho RA: Diversificação Alimentar como parte de um Programa de Combate à Deficiência de Vitamina A. Nutrição em Pauta 2008, 88:5-9.
• [47]Ministério da Saúde: Pesquisa Nacional de Demografia da Saúde da Crianças e da Mulher. [http://bvsms.saude.gov.br/bvs/pnds/index.php] webcite
• [48]Dixon LB, Winkleby MA, Radimer KL: Dietary intakes and serum nutrients differ between adults from food-insufficient and food-sufficient families: Third National Health and Nutrition Examination Survey, 1988-1994. J Nutr 2001, 131(4):1232-46.
• [49]Mishra GD, Malik NS, Paul AA, Wadsworth MEJ, Bolton-Smith C: Childhood and adult dietary vitamin E intake and cardiovascular risk factor in mid life in the 1946 British Birth Cohort. Eur J Clin Nutr 2003, 57:1418-25.
• [50]Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS: Vitamin E and cognitive decline in older persons. Arch Neurol 2002, 59:1125-32.
• [51]Horwitt MK: Critique of the requirement for vitamin E. Am J Clin Nutr 2001, 73:1003-5.
• [52]Traber MG: Vitamin E: too much or not enough? Am J Clin Nutr 2001, 73:987-98.
• [53]Beitz R, Mensink GBM, Fischer B, Thamm M: Vitamins dietary intake and intake from dietary supplements in Germany. Eur J Clin Nutr 2002, 56:539-45.
• [54]Sichert-Hellert W, Kersting M, Manz F: Changes in time-trends of nutrient intake from fortified and non-fortified food in German children and adolescents: 15 year results of the DONALD Study. Eur J Nutr 2001, 40:49-55.
• [55]Navarro-Alarcon M, Cabrera-Vique C: Selenium in food and the human body: a review. Sci Total Environ 2008, 400:115-41.
• [56]Gonzaga IB, Martens A, Cozzolino MF: Biodisponibilidade de nutrientes. São Paulo: Manole; 2005.
• [57]Freitas SC, Gonçalves EB: Meta-análise do teor de selênio em castanha-do-brasil. Braz J Food Technol 2008, 11:54-62.
• [58]Cozzolino SMF: Deficiências de minerais. Estudos Avançados 2007, 21:119-26.
• [59]Boquist L, Lernmark A: Effects on the endocrine pancreas in Chinese Hamsters fed zinc deficient diets. Acta Pathol Microbiol Scand 1969, 6:215.
• [60]Soinio M, Marniemi J, Laakso M, Pyörälä K, Lehto S, Rönnemaa T: Serum zinc level and coronary heart disease events in patients with type 2 diabetes. Diabetes Care 2007, 30:523-8.
• [61]Marreiro DN, Fisberg M, Cozzolino SM: Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res 2004, 100:137-49.
• [62]Shills ME, Olson JA, Shike M, Ross AC: Modern Nutrition in Health and Disease. Dona Balado; 1999.
• [63]Madruga de Oliveira A, Rondó PH, Barros SP: Concentrations of ascorbic acid in the plasma of pregnant smokers and non-smokers and their newborns. Int J Vitam Nutr Res 2004, 74:193-8.
• [64]Hoffmann K, Boeing H, Dufour A, Volatier JL, Telman J, Virtanen M, et al.: Estimating the distribution of usual dietary intake by short-term measurements. Eur J Clin Nutr 2002, 56:53-62.