Subthalamic nucleus deep brain stimulation for Parkinson’s disease: 8 years of follow-up

Translational Neurodegeneration

Bomin Sun¹  Shengdi Chen²  Shikun Zhan¹  Jing Zhang¹  Chunyan Cao¹  Dianyou Li¹ 

[1] Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

关键词: Subthalamic nucleus;    Parkinson’s disease;    Long-term effects;    Deep brain stimulation;   

Others  :  838693
DOI  :  10.1186/2047-9158-2-11

 received in 2013-04-18, accepted in 2013-05-13,  发布年份 2013

【 摘 要 】

Objective

The short-term benefits of bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson’s disease (PD) are well documented, but long-term benefits are still uncertain. The aim of this study is to evaluate the outcome of 8 years of bilateral STN stimulation to PD patients.

Methods

In this study, 31 consecutive PD patients were treated with bilateral STN stimulation. Their functional status was measured using the Activities of Daily Living section of the Unified Parkinson’s Disease Rating Scale (UPDRS-ADL) at drug on (with medication) and drug off (without medication) states preoperatively and at 1, 5, and 8 years postoperatively. In addition, Levodopa equivalent doses and stimulation parameters were also assessed.

Results

After 8 years of STN stimulation, the UPDRS-ADL scores were improved by 4% at drug off status (P > 0.05) and 22% at drug on status (P < 0.05) compared with baseline; the levodopa daily doses were reduced by 28% (P < 0.05) compared with baseline; the stimulation voltage and pulse width were not changed, but the stimulation frequency was decreased remarkably compared with the 5 years of follow-up. Adverse events were observed in 6 patients, including misplacement of the electrode and skin erosion requiring further surgery. All events were resolved without permanent sequelae. 2 patients died of aspiration pneumonia 6 and 7 years after surgery.

Conclusions

The marked improvement in UPDRS-ADL scores were still observed after 8 years of bilateral STN stimulation with medication.

【 授权许可】

   
2013 Li et al.; licensee BioMed Central Ltd.

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