Intensity modulated radiotherapy for elderly bladder cancer patients

Radiation Oncology

Pei-Wei Shueng²  Yen-Ping Hsieh³  Li-Ying Wang⁶  Yu-Jen Chen¹  Ngot-Swan Chong⁸  Le-Jung Wu⁸  Chi-Huang Hsiao⁵  Hsiao-Chun Chang⁷  Siu-Kai Lai⁷  Pei-Hui Chan⁷  Shiu-Dong Chung⁷  Chen-Hsi Hsieh⁴ 

[1] Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan;Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan;Department of Healthcare Administration, Asia University, Taichung, Taiwan;Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan;Division of Medical Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan;School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan;Division of Urology, Far Eastern Memorial Hospital, Taipei, Taiwan;Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, Taipei, Taiwan

关键词: Intensity modulated radiation therapy;    Helical tomotherapy;    Concurrent chemoradiation;    Bladder cancer;   

Others  :  1224322
DOI  :  10.1186/1748-717X-6-75

 received in 2011-03-12, accepted in 2011-06-16,  发布年份 2011

【 摘 要 】

Background

To review our experience and evaluate treatment planning using intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) for the treatment of elderly patients with bladder cancer.

Methods

From November 2006 through November 2009, we enrolled 19 elderly patients with histologically confirmed bladder cancer, 9 in the IMRT and 10 in the HT group. The patients received 64.8 Gy to the bladder with or without concurrent chemotherapy. Conventional 4-field "box" pelvic radiation therapy (2DRT) plans were generated for comparison.

Results

The median patient age was 80 years old (range, 65-90 years old). The median survival was 21 months (5 to 26 months). The actuarial 2-year overall survival (OS) for the IMRT vs. the HT group was 26.3% vs .37.5%, respectively; the corresponding values for disease-free survival were 58.3% vs. 83.3%, respectively; for locoregional progression-free survival (LRPFS), the values were 87.5% vs. 83.3%, respectively; and for metastases-free survival, the values were 66.7% vs. 60.0%, respectively. The 2-year OS rates for T1, 2 vs. T3, 4 were 66.7% vs. 35.4%, respectively (p = 0.046). The 2-year OS rate was poor for those whose RT completion time greater than 8 weeks when compared with the RT completed within 8 wks (37.9% vs. 0%, p = 0.004).

Conclusion

IMRT and HT provide good LRPFS with tolerable toxicity for elderly patients with invasive bladder cancer. IMRT and HT dosimetry and organ sparing capability were superior to that of 2DRT, and HT provides better sparing ability than IMRT. The T category and the RT completion time influence OS rate.

【 授权许可】

   
2011 Hsieh et al; licensee BioMed Central Ltd.

【 图 表 】

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