Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays

Thrombosis Journal

François Mullier²  Jean-Michel Dogné³  Catherine Goffinet¹  Bernard Chatelain²  Anne Tamigniau²  Jonathan Douxfils³ 

[1] Clinique et Maternité Sainte-Elisabeth, Namur, Belgium;Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), CHU Dinant Godinne UcL Namur, Université Catholique de Louvain, 1, avenue Dr Gaston Therasse, B5530 Yvoir, Belgium;Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for LIfe Sciences (NARILIS), University of Namur, Namur, Belgium

关键词: Non-VKA oral anticoagulants;    Monitoring;    Enoxaparin;    Low molecular weight heparin;    Apixaban;    Rivaroxaban;    Dabigatran;    Vitamin K antagonist;   

Others  :  1135349
DOI  :  10.1186/1477-9560-12-24

 received in 2014-03-11, accepted in 2014-10-06,  发布年份 2014

【 摘 要 】

Traditional anticoagulant agents such as vitamin K antagonists (VKAs), unfractionated heparin (UFH), low molecular weight heparins (LMWHs) and fondaparinux have been widely used in the prevention and treatment of thromboembolic diseases. However, these agents are associated with limitations, such as the need for regular coagulation monitoring (VKAs and UFH) or a parenteral route of administration (UFH, LMWHs and fondaparinux).

Several non-VKA oral anticoagulants (NOACs) are now widely used in the prevention and treatment of thromboembolic diseases and in stroke prevention in non-valvular atrial fibrillation. Unlike VKAs, NOACs exhibit predictable pharmacokinetics and pharmacodynamics. They are therefore usually given at fixed doses without routine coagulation monitoring. However, in certain patient populations or special clinical circumstances, measurement of drug exposure may be useful, such as in suspected overdose, in patients experiencing a hemorrhagic or thromboembolic event during the treatment’s period, in those with acute renal failure, in patients who require urgent surgery or in case of an invasive procedure. This article aims at providing guidance on laboratory testing of classic anticoagulants and NOACs.

【 授权许可】

   
2014 Douxfils et al.; licensee BioMed Central Ltd.

【 图 表 】

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