Phylogenetic exploration of hantaviruses in paraguay reveals reassortment and host switching in South America

Virology Journal

Colleen B Jonsson²  Robert D Owen¹  Yong-Kyu Chu³ 

[1] Martín Barrios 2230 c/Pizarro, Barrio Republicano, Asunción, Paraguay;Department of Microbiology and Immunology, University of Louisville, KY, 40222 USA;Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Louisville, KY 40222 USA

关键词: Akodon, Oligoryzomys;    phylogenetics;    emerging pathogens;    ecology;    zoonotic pathogens;    host switching;    reassortment;    Hantavirus;   

Others  :  1156310
DOI  :  10.1186/1743-422X-8-399

 received in 2011-07-26, accepted in 2011-08-12,  发布年份 2011

【 摘 要 】

Background

Longitudinal mark-recapture studies of rodents in two sites in the Mbaracayú Biosphere Reserve in the Interior Atlantic Forest of eastern Paraguay have revealed a complex and intriguing pattern of hantaviruses harbored by rodents in this area. Full-length sequencing and phylogenetic analyses were conducted for several rodents from Akodon montensis and Oligoryzomys fornesi. The phylogenetic relationships of these viruses were analyzed in the context of hantaviruses in South America with published S- and M-segment sequences.

Findings

Phylogenetic analyses of hantaviruses identified in the Mbaracayú Biosphere Reserve in Paraguay revealed Jabora and Juquitiba viruses are harbored by Akodon montensis and Oligoryzomys fornesi, respectively. These analyses revealed that in general the constituents of the major subclade for the S- and M-segments differ for the South American hantaviruses. Further, the two major groups within subclade C for the M-segment reflect in general the lethality associated with the viruses within each group.

Conclusions

Phylogenetic studies of Jabora and Juquitiba viruses and other Paraguayan viruses in the context of American hantaviruses revealed reassortment and host-switching in the evolution of South American hantaviruses.

【 授权许可】

   
2011 Chu et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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