Correlation of the oxygen radical activity and antioxidants and severity in critically ill surgical patients – study protocol

World Journal of Emergency Surgery

Jae Gil Lee¹  Seung Hwan Lee¹  Ji Young Jang¹  Hongjin Shim² 

[1] Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea;Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea

关键词: Glutamate;    Selenium;    Zinc;    Critically ill patient;    Sepsis;    Antioxidant activity;    Oxygen radical activity;   

Others  :  791903
DOI  :  10.1186/1749-7922-8-18

 received in 2013-02-23, accepted in 2013-04-26,  发布年份 2013

【 摘 要 】

Background

Surgical patients who require an emergent operation commonly have severe sepsis or septic shock, followed by high morbidity and mortality rates.

Despite advances in treatment however, no predictable markers are available. In severe sepsis, many pathophysiologic mechanisms are involved in progression to organ failure, and oxygen free radical and antioxidants are known to contribute to this process. Oxygen free radical and antioxidants contribute to progression of organ failure in severe sepsis. In fact, oxygen radical activity has been reported to be correlated with disease severity and prognosis in patients with severe sepsis or septic shock. Accordingly, we aim to assess the usefulness of oxygen free radical and antioxidant concentrations to predict the disease severity and mortality in a cohort of critically ill surgical patients.

Methods/Design

This is a prospective observation study including patient demographic characteristics, clinical information, blood sampling/serum oxygen radical activity, serum antioxidant activity, serum antioxidant concentrations (zinc, selenium and glutamate), disease severity scores, outcomes, lengths of stay in intensive care unit, hospital 30-day mortality.

【 授权许可】

   
2013 Shim et al.; licensee BioMed Central Ltd.

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