ICON: chronic rhinosinusitis

World Allergy Organization Journal

Michael Blaiss^1,15  Richard Voegels⁹  Harumi Suzaki⁴  Chae-Seo Rhee¹  Renata Pilan²  Robert Naclerio⁶  Joaquim Mullol³  Eli O Meltzer^1,12  Robert Kern^1,13  Orathai Jirapongsananuruk⁸  Daniel L Hamilos⁷  Wytske J Fokkens⁵  Chaweewan Bunnag⁸  Luo Zhang^1,11  Ruby Pawankar^1,14  Claus Bachert^1,10 

[1] Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Seoul National University College of Medicine, Seoul, Korea;Department of Otorhinolaryngology, Clinics Hospital/University of Sao Paulo Medical School, Brazil;Rhinology Unit & Smell Clinic, Hospital Clínic – IDIBAPS, Barcelona, Catalonia, Spain;Dept. of Otorhinolaryngology, Showa University, Tokyo, Japan;Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands;Section of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA;Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, USA;Faculty of Medicine, Siriraj Hospital Mahidol University, Bangkok, Thailand;Department of Rhinology, University of Sao Paulo Medical School, Sao Paulo, Brazil;Upper Airways Research Laboratory (URL), University Hospital Ghent, Belgium;Beijing Key Laboratory of Nasal diseases, Beijing Institute of Otolaryngology, Beijing, China;Allergy & Asthma Medical Group & Research Center, San Diego, California, USA;Department of Otolaryngology Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA;Div. of Allergy, Dept. of Pediatrics, Nippon Medical School, Tokyo, Japan;University of Tennessee Health Science Center, Memphis, Tennessee

关键词: Unmet needs;    Biologicals;    Treatment;    Co-morbidities;    Genetics;    Phenotypes;    Pathophysiology;    Pharmacoeconomics;    Chronic rhinosinusitis;   

Others  :  1145477
DOI  :  10.1186/1939-4551-7-25

 received in 2014-08-27, accepted in 2014-08-27,  发布年份 2014

【 摘 要 】

Chronic rhinosinusitis (CRS) is a public health problem that has a significant socio-economic impact. Moreover, the complexity of this disease due to its heterogeneous nature based on the underlying pathophysiology - leading to different disease variants - further complicates our understanding and directions for the most appropriate targeted treatment strategies. Several International/national guidelines/position papers and/or consensus documents are available that present the current knowledge and treatment strategies for CRS. Yet there are many challenges to the management of CRS especially in the case of the more severe and refractory forms of disease. Therefore, the International Collaboration in Asthma, Allergy and Immunology (iCAALL), a collaboration between EAACI, AAAAI, ACAAI, and WAO, has decided to propose an International Consensus (ICON) on Chronic Rhinosinusitis. The purpose of this ICON on CRS is to highlight the key common messages from the existing guidelines, the differences in recommendations as well as the gaps in our current knowledge of CRS, thus providing a concise reference. In this document we discuss the definition of the disease, its relevance, pharmacoeconomics, pathophysiology, phenotypes and endotypes, genetics and risk factors, natural history and co-morbidities as well as clinical manifestations and treatment options in both adults and children comprising pharmacotherapy, surgical interventions and more recent biological approaches. Finally, we have also highlighted the unmet needs that wait to be addressed through future research.

【 授权许可】

   
2014 Bachert et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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