Functional outcome, cognition and quality of life after out-of-hospital cardiac arrest and therapeutic hypothermia: data from a randomized controlled trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Maaret Castrén³  Tero Varpula²  Markus Skrifvars²  Ville Pettilä²  Kirsi-Maija Kaukonen²  Tuomas Oksanen²  Erja Poutiainen¹  Marjaana Tiainen⁴ 

[1] Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland;Intensive Care Units, Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland;Helsinki University and HUCH Emergency Care, Helsinki University Hospital, Helsinki, Finland;Department of Neurology, Helsinki University Hospital, Haartmaninkatu 4, Helsinki 00029, Finland

关键词: Hypothermia;    Quality of life;    Cognition;    Neurological outcome;    Cardiac arrest;   

Others  :  1132258
DOI  :  10.1186/s13049-014-0084-9

 received in 2014-08-22, accepted in 2014-12-30,  发布年份 2015

【 摘 要 】

Background

To study functional neurologic and cognitive outcome and health-related quality of life (HRQoL) in a cohort of patients included in a randomised controlled trial on glucose control following out-of-hospital cardiac arrest (OHCA) from ventricular fibrillation (VF) treated with therapeutic hypothermia.

Methods

Patients alive at 6 months after being discharged from the hospital underwent clinical neurological and extensive neuropsychological examinations. Functional outcome was evaluated with the Cerebral Performance Category scale, the modified Rankin scale and the Barthel Index. Cognitive outcome was evaluated by neuropsychological test battery including two measures of each cognitive function: cognitive speed, execution, memory, verbal skills and visuospatial performance. We also assessed quality of life with a HRQoL 15D questionnaire.

Results

Of 90 OHCA-VF patients included in the original trial, 57 were alive at 6 months. Of these, 52 (91%) were functionally independent and 54 (95%) lived at their previous home. Focal neurological deficits were scarce. Intact cognitive performance was observed in 20 (49%), mild to moderate deficits in 14 (34%) and severe cognitive deficits in 7 (17%) of 41 patients assessed by a neuropsychologist. Cognitive impairments were most frequently detected in executive and memory functions. HRQoL of the CA survivors was comparable to that of age- and gender matched population.

Conclusions

Functional outcome six months after OHCA and therapeutic hypothermia was good in the great majority of the survivors, and half of them were cognitively intact. Of note, the HRQoL of CA survivors did not differ from that of age- and gender matched population.

【 授权许可】

   
2015 Tiainen et al.; licensee BioMed Central.

【 图 表 】

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