Trafficking regulation of proteins in Alzheimer’s disease

Molecular Neurodegeneration

Yun-wu Zhang²  Huaxi Xu¹  Guojun Bu³  Xian Zhang²  Yanfang Li²  Shangtong Jiang² 

[1] Degenerative Disease Research Program, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA;Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China;Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA

关键词: Trafficking;    Alzheimer’s disease;    A Disintegrin and Metalloprotease 10;    γ-secretase;    Beta-site APP-cleaving enzyme 1;    β-secretase;    Amyloid beta (A4) precursor protein;    α-secretase;   

Others  :  861736
DOI  :  10.1186/1750-1326-9-6

 received in 2013-11-29, accepted in 2013-12-15,  发布年份 2014

【 摘 要 】

The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer’s disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.

【 授权许可】

   
2014 Jiang et al.; licensee BioMed Central Ltd.

【 图 表 】

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