期刊论文详细信息
World Journal of Surgical Oncology
Pancreatic metastases from renal cell carcinoma: a case report and literature review of the clinical and radiological characteristics
Yoshiro Ogata1  Kenji Kobayashi1  Junji Furukawa1  Masaru Kimata1  Toshiaki Terauchi1  Homare Ito1  Yohei Masugi2  Yuki Kimura1  Hiroharu Shinozaki1  Yoshinori Hoshino1 
[1] Department of Surgery, Saiseikai Utsunomiya Hospital, 911-1 Takebayashi, Utsunomiya 321-0974, Japan;Department of Pathology, Keio University, School of Medicine, 35 Shinanomachi, Tokyo 165-8582, Japan
关键词: Radiological characteristics;    Imaging;    Renal cell carcinoma;    Surgery;    Pancreatic metastasis;   
Others  :  820954
DOI  :  10.1186/1477-7819-11-289
 received in 2013-05-29, accepted in 2013-10-25,  发布年份 2013
PDF
【 摘 要 】

Metastatic pancreatic cancer is rare, accounting for approximately 2% of all pancreatic malignancies, and most cases arise from renal cell carcinoma. We report the case of a 63-year-old woman, who presented with a pancreatic tumor detected during her annual health examination. She had undergone left nephrectomy 13 years previously for renal cell carcinoma. Computed tomography (CT) revealed two tumors in the head and body of the pancreas, a hypervascular tumor and a hypovascular tumor with an enhanced rim, respectively. She underwent pylorus-preserving pancreaticoduodenectomy, and metastatic pancreatic tumors arising from the kidney with clustered clear cell carcinoma immunohistochemically positive for CD10 were diagnosed. This report presents the different enhancement features of different lesions on CT scans. Because the enhancement features of lesions have been reported to vary according to the size of the metastatic tumor, a knowledge of the history of renal cell carcinoma is crucial for diagnosis.

【 授权许可】

   
2013 Hoshino et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20140712061946542.pdf 1186KB PDF download
Figure 3. 335KB Image download
Figure 2. 116KB Image download
Figure 1. 100KB Image download
【 图 表 】

Figure 1.

Figure 2.

Figure 3.

【 参考文献 】
  • [1]Bonapasta SA, Gregori M, Lanza R, Sangiorgi E, Menghi A, Scarpini M, Modesti M: Metastasis to the pancreas from breast cancer: difficulties in diagnosis and controversies in treatment. Breast Care (Basel) 2010, 5:170-173.
  • [2]Blazer DG 3rd, Ramirez PT, Wang H, Fleming JB: Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreas. JOP 2008, 9:56-60.
  • [3]Hernandez S, Martin-Fernandez J, Lasa I, Busteros I, Garcia-Moreno F: Pancreaticoduodenectomy for metastasis of uterine leiomyosarcoma to the pancreas. Clin Transl Oncol 2010, 12:643-645.
  • [4]Palmowski M, Hacke N, Satzl S, Klauss M, Wente MN, Neukamm M, Kleeff J, Hallscheidt P: Metastasis to the pancreas: characterization by morphology and contrast enhancement features on CT and MRI. Pancreatology 2008, 8:199-203.
  • [5]Sperti C, Pasquali C, Berselli M, Frison L, Vicario G, Pedrazzoli S: Metastasis to the pancreas from colorectal cancer: is there a place for pancreatic resection? Dis Colon Rectum 2009, 52:1154-1159.
  • [6]Crippa S, Angelini C, Mussi C, Bonardi C, Romano F, Sartori P, Uggeri F, Bovo G: Surgical treatment of metastatic tumors to the pancreas: a single center experience and review of the literature. World J Surg 2006, 30:1536-1542.
  • [7]Roland CF, van Heerden JA: Nonpancreatic primary tumors with metastasis to the pancreas. Surg Gynecol Obstet 1989, 168:345-347.
  • [8]Lopez-Cantarero Ballesteros M, Fuentes Porcel O, Perez Cabrera B, Perez Benitez F, Bustos De Abajo M, Jean B: Melanoma metastasis to the pancreas. Rev Esp Enferm Dig 1992, 82:61-62.
  • [9]Brodish RJ, McFadden DW: The pancreas as the solitary site of metastasis from melanoma. Pancreas 1993, 8:276-278.
  • [10]Pereira-Lima JC, Coral GP, Bayer LR, da Silva CP: Metastasis from colon carcinoma in the dorsal pancreas of a patient with pancreas divisum: report of a case. Hepatogastroenterology 2000, 47:554-555.
  • [11]Bachmann J, Michalski CW, Bergmann F, Buchler MW, Kleeff J, Friess H: Metastasis of rectal adenocarcinoma to the pancreas. Two case reports and a review of the literature. JOP 2007, 8:214-222.
  • [12]Sweeney AD, Wu MF, Hilsenbeck SG, Brunicardi FC, Fisher WE: Value of pancreatic resection for cancer metastatic to the pancreas. J Surg Res 2009, 156:189-198.
  • [13]Sellner F, Tykalsky N, De Santis M, Pont J, Klimpfinger M: Solitary and multiple isolated metastases of clear cell renal carcinoma to the pancreas: an indication for pancreatic surgery. Ann Surg Oncol 2006, 13:75-85.
  • [14]Zerbi A, Ortolano E, Balzano G, Borri A, Beneduce AA, Di Carlo V: Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection? Ann Surg Oncol 2008, 15:1161-1168.
  • [15]Eidt S, Jergas M, Schmidt R, Siedek M: Metastasis to the pancreas – an indication for pancreatic resection? Langenbecks Arch Surg 2007, 392:539-542.
  • [16]Karimi KM, McFadden DW: Pancreatic resection for metastatic renal cell carcinoma to the pancreas. Am Surg 2007, 73:1158-1160.
  • [17]Sohn TA, Yeo CJ, Cameron JL, Nakeeb A, Lillemoe KD: Renal cell carcinoma metastatic to the pancreas: results of surgical management. J Gastrointest Surg 2001, 5:346-351.
  • [18]Imanaga H: A new method of pancreaticoduodenectomy designed to preserve liver and pancreatic function. Surgery 1960, 47:577-586.
  • [19]Pantuck AJ, Zisman A, Belldegrun AS: The changing natural history of renal cell carcinoma. J Urol 2001, 166:1611-1623.
  • [20]Motzer RJ, Bander NH, Nanus DM: Renal-cell carcinoma. N Engl J Med 1996, 335:865-875.
  • [21]Sahin M, Foulis AA, Poon FW, Imrie CW: Late focal pancreatic metastasis of renal cell carcinoma. Dig Surg 1998, 15:72-74.
  • [22]Thompson LD, Heffess CS: Renal cell carcinoma to the pancreas in surgical pathology material. Cancer 2000, 89:1076-1088.
  • [23]Hung JH, Wang SE, Shyr YM, Su CH, Chen TH, Wu CW: Resection for secondary malignancy of the pancreas. Pancreas 2012, 41:121-129.
  • [24]Machado NO, Chopra P: Pancreatic metastasis from renal carcinoma managed by Whipple resection. A case report and literature review of metastatic pattern, surgical management and outcome. JOP 2009, 10:413-418.
  • [25]David AW, Samuel R, Eapen A, Vyas F, Joseph P, Sitaram V: Pancreatic metastasis from renal cell carcinoma 16 years after nephrectomy: a case report and review of the literature. Trop Gastroenterol 2006, 27:175-176.
  • [26]Bassi C, Butturini G, Falconi M, Sargenti M, Mantovani W, Pederzoli P: High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma. Br J Surg 2003, 90:555-559.
  • [27]Reddy S, Edil BH, Cameron JL, Pawlik TM, Herman JM, Gilson MM, Campbell KA, Schulick RD, Ahuja N, Wolfgang CL: Pancreatic resection of isolated metastases from nonpancreatic primary cancers. Ann Surg Oncol 2008, 15:3199-3206.
  • [28]Hirota T, Tomida T, Iwasa M, Takahashi K, Kaneda M, Tamaki H: Solitary pancreatic metastasis occurring eight years after nephrectomy for renal cell carcinoma. A case report and surgical review. Int J Pancreatol 1996, 19:145-153.
  • [29]Muranaka T, Teshima K, Honda H, Nanjo T, Hanada K, Oshiumi Y: Computed tomography and histologic appearance of pancreatic metastases from distant sources. Acta Radiol 1989, 30:615-619.
  • [30]Ferrozzi F, Bova D, Campodonico F, Chiara FD, Passari A, Bassi P: Pancreatic metastases: CT assessment. Eur Radiol 1997, 7:241-245.
  • [31]Maeno T, Satoh H, Ishikawa H, Yamashita YT, Naito T, Fujiwara M, Kamma H, Ohtsuka M, Hasegawa S: Patterns of pancreatic metastasis from lung cancer. Anticancer Res 1998, 18:2881-2884.
  • [32]Klein KA, Stephens DH, Welch TJ: CT characteristics of metastatic disease of the pancreas. Radiographics 1998, 18:369-378.
  • [33]Boudghene FP, Deslandes PM, LeBlanche AF, Bigot JM: US and CT imaging features of intrapancreatic metastases. J Comput Assist Tomogr 1994, 18:905-910.
  • [34]Ng CS, Loyer EM, Iyer RB, David CL, DuBrow RA, Charnsangavej C: Metastases to the pancreas from renal cell carcinoma: findings on three-phase contrast-enhanced helical CT. AJR Am J Roentgenol 1999, 172:1555-1559.
  • [35]Scatarige JC, Horton KM, Sheth S, Fishman EK: Pancreatic parenchymal metastases: observations on helical CT. AJR Am J Roentgenol 2001, 176:695-699.
  • [36]Faure JP, Tuech JJ, Richer JP, Pessaux P, Arnaud JP, Carretier M: Pancreatic metastasis of renal cell carcinoma: presentation, treatment and survival. J Urol 2001, 165:20-22.
  • [37]Yachida S, Fukushima N, Kanai Y, Nimura S, Shimada K, Yamamoto J, Sakamoto M: Pancreatic metastasis from renal cell carcinoma extending into the main pancreatic duct: a case report. Jpn J Clin Oncol 2002, 32:315-317.
  • [38]Zacharoulis D, Asopa V, Karvounis E, Williamson RC: Resection of renal metastases to the pancreas: a surgical challenge. HPB (Oxford) 2003, 5:137-141.
  • [39]Mecho S, Quiroga S, Cuellar H, Sebastia C: Pancreatic metastasis of renal cell carcinoma: multidetector CT findings. Abdom Imaging 2009, 34:385-389.
  • [40]You DD, Choi DW, Choi SH, Heo JS, Kim WS, Ho CY, Lee HG: Surgical resection of metastasis to the pancreas. J Korean Surg Soc 2011, 80:278-282.
  • [41]Katsourakis A, Noussios G, Hadjis I, Alatsakis M, Chatzitheoklitos E: Late solitary pancreatic metastasis from renal cell carcinoma: a case report. Case Rep Med 2012, 2012:464808.
  • [42]Atiq M, Bhutani MS, Ross WA, Raju GS, Gong Y, Tamm EP, Javle M, Wang X, Lee JH: Role of endoscopic ultrasonography in evaluation of metastatic lesions to the pancreas: a tertiary cancer center experience. Pancreas 2012, 42:516-523.
  • [43]Comunoglu C, Altaca G, Demiralay E, Moray G: Multiple metastatic renal cell carcinoma isolated to pancreas. Malays J Pathol 2012, 34:63-66.
  • [44]Yazbek T, Gayet B: The place of enucleation and enucleo-resection in the treatment of pancreatic metastasis of renal cell carcinoma. JOP 2012, 13:433-438.
  • [45]Ramdave S, Thomas GW, Berlangieri SU, Bolton DM, Davis I, Danguy HT, Macgregor D, Scott AM: Clinical role of F-18 fluorodeoxyglucose positron emission tomography for detection and management of renal cell carcinoma. J Urol 2001, 166:825-830.
  • [46]Majhail NS, Urbain JL, Albani JM, Kanvinde MH, Rice TW, Novick AC, Mekhail TM, Olencki TE, Elson P, Bukowski RM: F-18 fluorodeoxyglucose positron emission tomography in the evaluation of distant metastases from renal cell carcinoma. J Clin Oncol 2003, 21:3995-4000.
  • [47]Wente MN, Kleeff J, Esposito I, Hartel M, Muller MW, Frohlich BE, Buchler MW, Friess H: Renal cancer cell metastasis into the pancreas: a single-center experience and overview of the literature. Pancreas 2005, 30:218-222.
  • [48]Masetti M, Zanini N, Martuzzi F, Fabbri C, Mastrangelo L, Landolfo G, Fornelli A, Burzi M, Vezzelli E, Jovine E: Analysis of prognostic factors in metastatic tumors of the pancreas: a single-center experience and review of the literature. Pancreas 2010, 39:135-143.
  • [49]Tanis PJ, van der Gaag NA, Busch OR, van Gulik TM, Gouma DJ: Systematic review of pancreatic surgery for metastatic renal cell carcinoma. Br J Surg 2009, 96:579-592.
  • [50]Mehta N, Volpe C, Haley T, Balos L, Bradley EL 3rd, Doerr RJ: Pancreaticoduodenectomy for metastatic renal cell carcinoma: report of a case. Surg Today 2000, 30:94-97.
  • [51]Bechade D, Palazzo L, Desrame J, Duvic C, Herody M, Didelot F, Coutant G, Algayres JP: Pancreatic metastasis of renal cell carcinoma: report of three cases. Rev Med Interne 2002, 23:862-866.
  • [52]Eloubeidi MA, Jhala D, Chhieng DC, Jhala N, Eltoum I, Wilcox CM: Multiple late asymptomatic pancreatic metastases from renal cell carcinoma: diagnosis by endoscopic ultrasound-guided fine needle aspiration biopsy with immunocytochemical correlation. Dig Dis Sci 2002, 47:1839-1842.
  • [53]Butturini G, Bassi C, Falconi M, Salvia R, Caldiron E, Iannucci A, Zamboni G, Graziani R, Procacci C, Pederzoli P: Surgical treatment of pancreatic metastases from renal cell carcinomas. Dig Surg 1998, 15:241-246.
  • [54]Kassabian A, Stein J, Jabbour N, Parsa K, Skinner D, Parekh D, Cosenza C, Selby R: Renal cell carcinoma metastatic to the pancreas: a single-institution series and review of the literature. Urology 2000, 56:211-215.
  • [55]Ghavamian R, Klein KA, Stephens DH, Welch TJ, LeRoy AJ, Richardson RL, Burch PA, Zincke H: Renal cell carcinoma metastatic to the pancreas: clinical and radiological features. Mayo Clin Proc 2000, 75:581-585.
  • [56]Law CH, Wei AC, Hanna SS, Al-Zahrani M, Taylor BR, Greig PD, Langer B, Gallinger S: Pancreatic resection for metastatic renal cell carcinoma: presentation, treatment, and outcome. Ann Surg Oncol 2003, 10:922-926.
  • [57]Varker KA, Muscarella P, Wall K, Ellison C, Bloomston M: Pancreatectomy for non-pancreatic malignancies results in improved survival after R0 resection. World J Surg Oncol 2007, 5:145. BioMed Central Full Text
  • [58]Schauer M, Vogelsang H, Siewert JR: Pancreatic resection for metastatic renal cell carcinoma: a single center experience and review of the literature. Anticancer Res 2008, 28:361-365.
  • [59]Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C, Warshaw AL, Ferrone CR: Metastatic tumors in the pancreas in the modern era. J Am Coll Surg 2010, 211:749-753.
  • [60]Gardini A, Morgagni P, Milandri C, Riccobon A, Ridolfi R, La Barba G, Saragoni L, Amadori D, Garcea D: Pancreatic resection for metastases from renal cancer: long term outcome after surgery and immunotherapy approach – single center experience. Hepatogastroenterology 2012, 59:687-690.
  文献评价指标  
  下载次数:19次 浏览次数:15次