Mucosal Alpha-Papillomavirus (HPV89) in a rare skin lesion

Virology Journal

Aldo Venuti²  Gianfranca Curzio²  Ada Amantea¹  Carlo Cota¹  Francesca Paolini² 

[1] Laboratory of Cutaneous Histopathology, San Gallicano Dermatologic Institute, Rome, Italy;HPV-UNIT Laboratory of Virology, Regina Elena National Cancer Institute, via Chianesi 53, Rome, 00144, Italy

关键词: Apocrine acrosyringeal keratosis;    Syringocystoadenoma papilliferum;    HPV 89;   

Others  :  1224903
DOI  :  10.1186/s12985-015-0336-y

 received in 2015-02-19, accepted in 2015-06-30,  发布年份 2015

【 摘 要 】

Background

Apocrine acrosyringeal keratosis is a rare skin lesion showing a unique benign keratotic lesion associated with syringocystoadenoma papilliferum. It is characterized by an exophytic proliferation of the epidermis with two distinct keratinocytic structures: a) columns of hyperkeratotic mass surrounded by acanthotic epidermis and b) papillated and/or cystic invaginations typical of syringocystoadenoma papilliferum. No causative agents were reported.

Findings

The present report describes a typical case of apocrine acrosyringeal keratosis localized in the right retro-auricular area of 57-year-old man in which the presence of HPV was evaluated. PCR analysis and direct sequencing revealed the presence of HPV 89. The presence of this low risk mucosal HPV in a skin localization was never reported as well as in association with this rare tumor. Furthermore rolling circle amplification, RT-PCR and in situ hybridization confirmed the presence of a transcriptionally active HPV 89.

Conclusions

Taken together our results suggest that HPV89 plays a role in apocrine acrosyringeal keratosis with syringocystoadenoma papilliferum, in consideration of the documented biological activity of the virus. The association of low risk mucosal HPV infection with this skin lesion opens new perspectives in its clinical management. Further studies on samples from other patients are needed to confirm this association.

【 授权许可】

   
2015 Paolini et al.

【 图 表 】

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