Weight loss reduces breast ductal fluid estrogens in obese postmenopausal women: a single arm intervention pilot study

Nutrition Journal

David Heber¹  Zhaoping Li¹  Susanne M Henning¹  Luyi Li¹  Patricia Jardack²  Karen Duvall⁴  Catherine L Carpenter³ 

[1] Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;General Clinical Research Center; David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA;School of Nursing, University of California at Los Angeles, Los Angeles, CA, USA;Center for Health Promotion and Disease Prevention; David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA

关键词: Breast ductal fluid;    Breast cancer;    Exercise;    Diet;    Postmenopausal;    Obesity;   

Others  :  823808
DOI  :  10.1186/1475-2891-11-102

 received in 2012-03-30, accepted in 2012-11-30,  发布年份 2012

【 摘 要 】

Background

Accumulation of excess body fat increases breast cancer risk after menopause. Whether the localized breast is differently influenced by adipose tissue compared to the rest of the body, has not been well studied. Our purpose was to demonstrate feasibility and preliminarily evaluate serum-based and localized breast biomarker changes resulting from a weight loss intervention among obese postmenopausal women.

Methods

We conducted a 12-week pilot controlled dietary and exercise intervention among healthy obese postmenopausal women, collected serum and breast ductal fluid before and after the intervention, and estimated the association with systemic and localized biomarker changes. We recruited 7 obese (mean body mass index = 33.6 kg/m²) postmenopausal women. We collected samples at baseline and the 12th week for: anthropometry; phlebotomy; dual-energy x-ray absorptiometry (lean and fat mass); exercise fitness (maximum oxygen consumption (VO₂Max); 1-repetition strength maximum); and breast ductal lavage.

Results

Changes from baseline occurred in body composition and exercise performance including fat mass loss (14% average drop), VO₂Max (+36% increase) and strength improvement (+26%). Breast ductal fluid markers declined from baseline with estradiol showing a 24% reduction and IL-6 a 20% reduction. We also observed serum biomarker reductions from baseline including leptin (36% decline), estrone sulfate (−10%), estradiol (−25%), and Il-6 (−33%).

Conclusions

Conduct of the diet and exercise intervention, collection of ductal fluid, and measurement of hormones and cytokines contained in the ductal fluid were all feasible. We preliminarily demonstrated estradiol and IL-6 reductions from baseline in both serum and breast ductal fluid among obese postmenopausal women who participated in the 12-week weight loss diet and exercise intervention.

【 授权许可】

   
2012 Carpenter et al.; licensee BioMed Central Ltd.

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