Sweet taste loss in myasthenia gravis: more than a coincidence?

Orphanet Journal of Rare Diseases

Thierry Kuntzer¹  Basile N Landis²  Anastasia Zekeridou¹  Muriel V Tschirren¹  Joelle N Chabwine¹ 

[1] Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland;Department of Otorhinolaryngology-Head and Neck Surgery, Geneva University Hospital, Geneva, Switzerland

关键词: Thymoma;    Myasthenia gravis;    Sweet taste;    Dysgeusia;   

Others  :  863212
DOI  :  10.1186/1750-1172-9-50

 received in 2014-02-06, accepted in 2014-04-08,  发布年份 2014

【 摘 要 】

Sweet dysgeusia, a rare taste disorder, may be encountered in severe anti-acetylcholine receptor antibody (AChRAb)-myasthenia gravis (MG). A 42 year-old man reported progressive loss of sweet taste evolving for almost 10 weeks, revealing an AChRAb-positive MG with thymoma. Improvement of sweet perception paralleled reduction of the MG composite score during the 15 months follow up period, with immunosuppressive and surgical treatments. We suggest that sweet dysgeusia is a non-motor manifestation of MG that may result from a thymoma-dependent autoimmune mechanism targeting gustducin-positive G-protein-coupled taste receptor cells, in line with recent data from MRL/MpJ-Fas^lpr/ (MRL/lpr) transgenic mice with autoimmune disease.

【 授权许可】

   
2014 Chabwine et al.; licensee BioMed Central Ltd.

【 图 表 】

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