Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control

Respiratory Research

Hironori Sagara²  Mitsuru Adachi¹  Takuya Yokoe²  Shintaro Suzuki²  Mayumi Yamamoto²  Yoshio Watanabe²  Shin Ohta²  Munehiro Yamaguchi²  Hiroko Mizuma²  Yoshito Miyata²  Kuniaki Hirai²  Megumi Jinno²  Akihiko Tanaka² 

[1] Department of Allergy, Sanno Hospital, Clinical Research Centers for Medicine, International University of Health and Welfare, Tokyo, Japan;Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan

关键词: house dust mite;    Aspergillus;    Severe asthma;    Longitudinal change;    IgE;   

Others  :  1137240
DOI  :  10.1186/s12931-014-0144-8

 received in 2014-09-13, accepted in 2014-11-03,  发布年份 2014

【 摘 要 】

Background

Immunoglobulin (Ig) E is well-known to play a critical role in allergic diseases. We investigated the association between longitudinal change in total IgE level and the asthma control in patients with adult asthma.

Methods

For this retrospective study, 154 patients with asthma aged 21–82 years were recruited from the allergy and pulmonary units of the Showa University Hospital. Data on longitudinal changes in IgE over the preceding 10 years were collected and logarithmically transformed. Associations between longitudinal change in IgE and clinical characteristics including asthma control test (ACT) score, asthma control, pulmonary function test, and antigen specific IgE, were assessed.

Results

Patients with increased IgE tended to have significantly higher mean age, more episodes of acute exacerbation within a year, lower ACT scores, and used oral corticosteroids more frequently than those with decreased or unchanged IgE. The prevalence of uncontrolled asthma was higher in patients with increased IgE than in those with decreased or unchanged IgE. Mean %FEV₁ and FEV_1% were lower in patients with increased IgE than in those with decreased or unchanged IgE. Moreover, the prevalence of Aspergillus-specific IgE was higher in patients with increased IgE than in those with decreased or unchanged IgE.

Conclusions

These data suggest that a longitudinal increase in total IgE is associated with both poor asthma control and Aspergillus-specific IgE in patients with adult asthma.

【 授权许可】

   
2014 Tanaka et al.; licensee BioMed Central Ltd.

【 图 表 】

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