Clinical outcome after IMSI procedure in an unselected infertile population: a pilot study

Reproductive Health

Marc Germond²  Françoise Urner²  Alain Chanson¹  Ilaria Soave³  Giuseppe Lo Monte³  Fabien Murisier²  Roberto Marci⁴ 

[1] CPMA, Centre of Reproductive Medicine, Rue de la Vigie 5, Lausanne 1003, Switzerland;FABER Foundation, Rue de la Vigie 5, Lausanne 1003, Switzerland;Department of Growth and Reproduction, Section of Gynecology and Obstetrics Infertility Unit, Sant'Anna University Hospital, via Aldo Moro 8, 44100, Cona (Ferrara), Italy;Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Corso Giovecca 183, Ferrara 44121, Italy

关键词: Sperm selection;    Sperm morphology;    Infertility;    IVF;    IMSI;    ICSI;   

Others  :  811696
DOI  :  10.1186/1742-4755-10-16

 received in 2012-10-05, accepted in 2013-03-08,  发布年份 2013

【 摘 要 】

Background

To date the IMSI procedure represents the only real-time and unstained method available to discard spermatozoa with ultrastructural defects. Several studies demonstrated that IMSI provides positive results in couples with severe male factor infertility or repeated ICSI failures. Aim of this pilot study is to evaluate the differences between IMSI and ICSI in terms of IVF outcomes in an unselected infertile patient population.

Methods

Three hundred and thirty-two couples were analyzed: 281 couples underwent conventional ICSI procedure and 51 underwent IMSI technique.

Results

No statistically significant differences were found between implantation rate (ICSI: 16,83%; IMSI: 16,67%), fertilization rate (ICSI: 77,27%; IMSI: 80,00%) and pregnancy rate (ICSI: 25,30%; IMSI: 23,50%). Both groups were comparable when considering live birth rate (ICSI: 11,39%; IMSI:13,72%), ongoing pregnancy rate (ICSI: 7,47%; IMSI: 5,88%) and miscarriage rate (ICSI: 17,78; IMSI: 5,26%). The subgroup analyses did not show a statistical difference between ICSI and IMSI neither in male factor infertility subgroup nor in patients with more than one previous ICSI attempt. A trend towards better laboratory and clinical outcomes was detected in the male factor infertility subgroup when IMSI was applied.

Conclusions

Our preliminary results show that the IMSI technique does not significantly improve IVF outcomes in an unselected infertile population.

【 授权许可】

   
2013 Marci et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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