Role of nutritional status in predicting quality of life outcomes in cancer – a systematic review of the epidemiological literature

Nutrition Journal

Pankaj G Vashi¹  Maurie Markman¹  Carolyn A Lammersfeld¹  Digant Gupta¹  Christopher G Lis¹ 

[1] Cancer Treatment Centers of America® (CTCA), 1336 Basswood Road, Schaumburg, IL, 60173, USA

关键词: Oncology;    Nutritional status;    Nutritional assessment;    Malnutrition;    Quality of life;   

Others  :  825680
DOI  :  10.1186/1475-2891-11-27

 received in 2012-02-01, accepted in 2012-04-24,  发布年份 2012

【 摘 要 】

Malnutrition is a significant factor in predicting cancer patients’ quality of life (QoL). We systematically reviewed the literature on the role of nutritional status in predicting QoL in cancer. We searched MEDLINE database using the terms “nutritional status” in combination with “quality of life” together with “cancer”. Human studies published in English, having nutritional status as one of the predictor variables, and QoL as one of the outcome measures were included. Of the 26 included studies, 6 investigated head and neck cancer, 8 gastrointestinal, 1 lung, 1 gynecologic and 10 heterogeneous cancers. 24 studies concluded that better nutritional status was associated with better QoL, 1 study showed that better nutritional status was associated with better QoL only in high-risk patients, while 1 study concluded that there was no association between nutritional status and QoL. Nutritional status is a strong predictor of QoL in cancer patients. We recommend that more providers implement the American Society of Parenteral and Enteral Nutrition (ASPEN) guidelines for oncology patients, which includes nutritional screening, nutritional assessment and intervention as appropriate. Correcting malnutrition may improve QoL in cancer patients, an important outcome of interest to cancer patients, their caregivers, and families.

【 授权许可】

   
2012 Lis et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Van Cutsem E, Arends J: The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 2005, 9:S51-S63. Suppl 2:S51-63
• [2]Isenring E, Bauer J, Capra S: The scored Patient-generated Subjective Global Assessment (PG-SGA) and its association with quality of life in ambulatory patients receiving radiotherapy. Eur J Clin Nutr 2003, 57:305-309.
• [3]Tong H, Isenring E, Yates P: The prevalence of nutrition impact symptoms and their relationship to quality of life and clinical outcomes in medical oncology patients. Support Care Cancer 2009, 17:83-90.
• [4]Bauer J, Capra S, Ferguson M: Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer. Eur J Clin Nutr 2002, 56:779-785.
• [5]Shahmoradi N, Kandiah M, Peng LS: Impact of nutritional status on the quality of life of advanced cancer patients in hospice home care. Asian Pac J Cancer Prev 2009, 10:1003-1009.
• [6]Trabal J, Leyes P, Forga MT, Hervas S: Quality of life, dietary intake and nutritional status assessment in hospital admitted cancer patients. Nutr Hosp 2006, 21:505-510.
• [7]Ravasco P, Monteiro-Grillo I, Camilo ME: Does nutrition influence quality of life in cancer patients undergoing radiotherapy? Radiother Oncol 2003, 67:213-220.
• [8]Capuano G, Gentile PC, Bianciardi F, Tosti M, Palladino A, Di Palma M: Prevalence and influence of malnutrition on quality of life and performance status in patients with locally advanced head and neck cancer before treatment. Support Care Cancer 2010, 18:433-437.
• [9]Marin Caro MM, Laviano A, Pichard C: Nutritional intervention and quality of life in adult oncology patients. Clin Nutr 2007, 26:289-301.
• [10]Norman K, Stobaus N, Zocher D, Bosy-Westphal A, Szramek A, Scheufele R, et al.: Cutoff percentiles of bioelectrical phase angle predict functionality, quality of life, and mortality in patients with cancer. Am J Clin Nutr 2010, 92:612-619.
• [11]Marin Caro MM, Laviano A, Pichard C: Impact of nutrition on quality of life during cancer. Curr Opin Clin Nutr Metab Care 2007, 10:480-487.
• [12]Hammerlid E, Wirblad B, Sandin C, Mercke C, Edstrom S, Kaasa S, et al.: Malnutrition and food intake in relation to quality of life in head and neck cancer patients. Head Neck 1998, 20:540-548.
• [13]Huhmann MB, Cunningham RS: Importance of nutritional screening in treatment of cancer-related weight loss. Lancet Oncol 2005, 6:334-343.
• [14]Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al.: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009, 339:b2700.
• [15]Moher D, Liberati A, Tetzlaff J, Altman DG: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010, 8:336-341.
• [16]Jager-Wittenaar H, Dijkstra PU, Vissink A, van der Laan BF, van Oort RP, Roodenburg JL: Malnutrition and quality of life in patients treated for oral or oropharyngeal cancer. Head Neck 2011, 33:490-496.
• [17]Morton RP, Crowder VL, Mawdsley R, Ong E, Izzard M: Elective gastrostomy, nutritional status and quality of life in advanced head and neck cancer patients receiving chemoradiotherapy. ANZ J Surg 2009, 79:713-718.
• [18]van den Berg MG, Rasmussen-Conrad EL, van Nispen L, van Binsbergen JJ, Merkx MA: A prospective study on malnutrition and quality of life in patients with head and neck cancer. Oral Oncol 2008, 44:830-837.
• [19]Petruson KM, Silander EM, Hammerlid EB: Quality of life as predictor of weight loss in patients with head and neck cancer. Head Neck 2005, 27:302-310.
• [20]Tian J, Chen ZC, Hang LF: Effects of nutritional and psychological status of the patients with advanced stomach cancer on physical performance status. Support Care Cancer 2009, 17:1263-1268.
• [21]Tian J, Chen ZC, Hang LF: The effects of nutrition status of patients with digestive system cancers on prognosis of the disease. Cancer Nurs 2008, 31:462-467.
• [22]Correia M, Cravo M, Marques-Vidal P, Grimble R, Dias-Pereira A, Faias S, et al.: Serum concentrations of TNF-alpha as a surrogate marker for malnutrition and worse quality of life in patients with gastric cancer. Clin Nutr 2007, 26:728-735.
• [23]Martin L, Lagergren J, Lindblad M, Rouvelas I, Lagergren P: Malnutrition after oesophageal cancer surgery in Sweden. Br J Surg 2007, 94:1496-1500.
• [24]Gupta D, Lis CG, Granick J, Grutsch JF, Vashi PG, Lammersfeld CA: Malnutrition was associated with poor quality of life in colorectal cancer: a retrospective analysis. J Clin Epidemiol 2006, 59:704-709.
• [25]Tian J, Chen JS: Nutritional status and quality of life of the gastric cancer patients in Changle County of China. World J Gastroenterol 2005, 11:1582-1586.
• [26]Andreyev HJ, Norman AR, Oates J, Cunningham D: Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? Eur J Cancer 1998, 34:503-509.
• [27]O'Gorman P, McMillan DC, McArdle CS: Impact of weight loss, appetite, and the inflammatory response on quality of life in gastrointestinal cancer patients. Nutr Cancer 1998, 32:76-80.
• [28]Scott HR, McMillan DC, Brown DJ, Forrest LM, McArdle CS, Milroy R: A prospective study of the impact of weight loss and the systemic inflammatory response on quality of life in patients with inoperable non-small cell lung cancer. Lung Cancer 2003, 40:295-299.
• [29]Gil KM, Gibbons HE, Jenison EL, Hopkins MP, von Gruenigen VE: Baseline characteristics influencing quality of life in women undergoing gynecologic oncology surgery. Health Qual Life Outcomes 2007, 5:25-25. BioMed Central Full Text
• [30]Norman K, Stobaus N, Smoliner C, Zocher D, Scheufele R, Valentini L, et al.: Determinants of hand grip strength, knee extension strength and functional status in cancer patients. Clin Nutr 2010, 29:586-591.
• [31]Nourissat A, Vasson MP, Merrouche Y, Bouteloup C, Goutte M, Mille D, et al.: Relationship between nutritional status and quality of life in patients with cancer. Eur J Cancer 2008, 44:1238-1242.
• [32]Ravasco P, Monteiro-Grillo I, Vidal PM, Camilo ME: Cancer: disease and nutrition are key determinants of patients' quality of life. Support Care Cancer 2004, 12:246-252.
• [33]Ovesen L, Hannibal J, Mortensen EL: The interrelationship of weight loss, dietary intake, and quality of life in ambulatory patients with cancer of the lung, breast, and ovary. Nutr Cancer 1993, 19:159-167.
• [34]Ravasco P, Monteiro-Grillo I, Marques VP, Camilo ME: Quality of life in gastrointestinal cancer: what is the impact of nutrition? Acta Med Port 2006, 19:189-196.
• [35]Shirodkar M, Mohandas KM: Subjective global assessment: a simple and reliable screening tool for malnutrition among Indians. Indian J Gastroenterol 2005, 24:246-250.
• [36]Wakahara T, Shiraki M, Murase K, Fukushima H, Matsuura K, Fukao A, et al.: Nutritional screening with Subjective Global Assessment predicts hospital stay in patients with digestive diseases. Nutrition 2007, 23:634-639.
• [37]Wu B, Yin TT, Cao W, Gu ZD, Wang X, Yan M, et al.: Validation of the Chinese version of the Subjective Global Assessment scale of nutritional status in a sample of patients with gastrointestinal cancer. Int J Nurs Stud 2010, 47:323-331.
• [38]Horsley P, Bauer J, Gallagher B: Poor nutritional status prior to peripheral blood stem cell transplantation is associated with increased length of hospital stay. Bone Marrow Transplant 2005, 35:1113-1116.