A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

Respiratory Research

Patricia J Sime¹  Martin Kolb²  Jack Gauldie² 

[1] Department of Medicine, Pulmonary and Critical Care Unit, University of Rochester School of Medicine, Rochester, New York, USA;Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada

关键词: transforming growth factor (TGF)-β;    tissue repair;    myofibroblast;    inflammation;    fibrosis;   

Others  :  1227421
DOI  :  10.1186/rr158

 received in 2001-07-30, accepted in 2001-08-08,  发布年份 2001

【 摘 要 】

A recent review article suggested that idiopathic pulmonary fibrosis (IPF) is a disease that is associated more with abnormal wound healing than with inflammation. Data derived from transgenic and gene transfer rodent models suggest that lung inflammation may be a necessary but insufficient component of IPF, and that at some point in the natural history of the disease IPF becomes no longer dependent on the inflammatory response for propagation. Altered microenvironment and involvement of epithelial cell/mesenchymal cell interaction are the most likely contributors to the pathogenesis of this chronic progressive disorder.

【 授权许可】

   
2001 BioMed Central Ltd

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