Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy

Molecular Pain

Ken-ichi Fukuda⁴  Kazutaka Ikeda¹  Takashi Kakizawa³  Shinya Kasai¹  Yoshito Takasaki⁵  Daisuke Nishizawa¹  Daisuke Kobayashi² 

[1] Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan;Department of Dentistry and Oral surgery, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashidai, Fuchu-shi, Tokyo 183-8524, Japan;Department of Oral Health and Clinical Science, Division of Oral and Maxillo-facial Surgery, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan;Department of Oral Health and Clinical Science, Division of Dental Anesthesiology, Orofacial Pain Center, Suidoubashi Hospital, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan;Department of Dentistry and Oral Surgery, National Hospital Organization, Takasaki General Medical Center, 36 Takamatsu-Cho, Takasaki-shi, Gunma 370-0829, Japan

关键词: Genome-wide association study;    Neuropathic pain;    Dysesthesia;    Hypoesthesia;    Bilateral sagittal split ramus osteotomy;   

Others  :  862401
DOI  :  10.1186/1744-8069-9-34

 received in 2013-03-19, accepted in 2013-05-28,  发布年份 2013

【 摘 要 】

Background

Bilateral sagittal split ramus osteotomy (BSSRO) is a common orthognatic surgical procedure. Sensory disturbances in the inferior alveolar nerve, including hypoesthesia and dysesthesia, are frequently observed after BSSRO, even without distinct nerve injury. The mechanisms that underlie individual differences in the vulnerability to sensory disturbances have not yet been elucidated.

Methods

The present study investigated the relationships between genetic polymorphisms and the vulnerability to sensory disturbances after BSSRO in a genome-wide association study (GWAS). A total of 304 and 303 patients who underwent BSSRO were included in the analyses of hypoesthesia and dysesthesia, respectively. Hypoesthesia was evaluated using the tactile test 1 week after surgery. Dysesthesia was evaluated by interview 4 weeks after surgery. Whole-genome genotyping was conducted using Illumina BeadChips including approximately 300,000 polymorphism markers.

Results

Hypoesthesia and dysesthesia occurred in 51 (16.8%) and 149 (49.2%) subjects, respectively. Significant associations were not observed between the clinical data (i.e., age, sex, body weight, body height, loss of blood volume, migration length of bone fragments, nerve exposure, duration of anesthesia, and duration of surgery) and the frequencies of hypoesthesia and dysesthesia. Significant associations were found between hypoesthesia and the rs502281 polymorphism (recessive model: combined χ² = 24.72, nominal P = 6.633 × 10^-7), between hypoesthesia and the rs2063640 polymorphism (recessive model: combined χ² = 23.07, nominal P = 1.563 × 10^-6), and between dysesthesia and the nonsynonymous rs2677879 polymorphism (trend model: combined χ² = 16.56, nominal P = 4.722 × 10^-5; dominant model: combined χ² = 16.31, nominal P = 5.369 × 10^-5). The rs502281 and rs2063640 polymorphisms were located in the flanking region of the ARID1B and ZPLD1 genes on chromosomes 6 and 3, whose official names are “AT rich interactive domain 1B (SWI1-like)” and “zona pellucida-like domain containing 1”, respectively. The rs2677879 polymorphism is located in the METTL4 gene on chromosome 18, whose official name is “methyltransferase like 4”.

Conclusions

The GWAS of sensory disturbances after BSSRO revealed associations between genetic polymorphisms located in the flanking region of the ARID1B and ZPLD1 genes and hypoesthesia and between a nonsynonymous genetic polymorphism in the METTL4 gene and dysesthesia.

【 授权许可】

   
2013 Kobayashi et al.; licensee BioMed Central Ltd.

【 图 表 】

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