Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children

Virology Journal

YoungJin Choi⁶  KyungAh Yoon⁸  HaeKyung Cheon¹  JaeWan Soh⁵  JoonSoo Park⁷  SangGu Yeo³  DooSung Cheon³  KyoungAh Baek⁴  BaeckHee Lee²  KwiSung Park⁴ 

[1] Department of Radiological Science, Baekseok Culture University, Cheonan, South Korea;JeongGene Pediatrics, Sejong, South Korea;Division of Vaccine Research, Center for Infectious Diseases, National Institute of Health, Korea Center for Disease Control and Prevention, Osong, South Korea;Chungcheongnam-Do Institute of Health and Environmental Research, Daejeon, South Korea;Department of Orthopedic Surgery, College of Medicine, Soonchunhyang University, Cheonan, South Korea;Departments of Laboratory Medicine, College of Medicine, Soonchunhyang University, Cheonan, South Korea;Department of Pediatrics, College of Medicine, Soonchunhyang University, Cheonan, South Korea;Department of Clinical Pathology, Daejeon Health Sciences College, Daejeon, South Korea

关键词: Enteroviruses;    Hand-foot-and-mouth disea1se;    Herpangina;   

Others  :  1153787
DOI  :  10.1186/1743-422X-9-205

 received in 2012-02-07, accepted in 2012-09-11,  发布年份 2012

【 摘 要 】

Hand-foot-and-mouth disease (HFMD) and herpangina are commonly prevalent illness in young children. They are similarly characterized by lesions on the skin and oral mucosa. Both diseases are associated with various enterovirus serotypes. In this study, enteroviruses from patients with these diseases in Korea in 2009 were isolated and analyzed. Demographic data for patients with HFMD and herpangina were compared and all enterovirus isolates were amplified in the VP1 region by reverse transcription-polymerase chain reaction and sequenced. Among the enterovirus isolates, prevalent agents were coxsackievirus A16 in HFMD and coxsackievirus A5 in herpangina. More prevalent months for HFMD were June (69.2%) and May (11.5%), and June (40.0%) and July (24.0%) for herpangina. Age prevalence of HFMD patients with enterovirus infection was 1 year (23.1%), 4 years (19.2%), and over 5 years (19.2%). However, the dominant age group of herpangina patients with enterovirus infection was 1 year (48.0%) followed by 2 years (28.0%). Comparison of pairwise VP1 nucleotide sequence alignment of all isolates within the same serotypes revealed high intra-type variation of CVA2 isolates (84.6–99.3% nucleotide identity). HFMD and herpangina showed differences in demographic data and serotypes of isolated enteroviruses, but there was no notable difference in amino acid sequences by clinical syndromes in multiple comparison of the partial VP1 gene sequence.

【 授权许可】

   
2012 Park et al.; licensee BioMed Central Ltd.

【 图 表 】

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