What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

Molecular Neurodegeneration

Christopher D Link¹  Dawn Teschendorf¹ 

[1] Institute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA

Others  :  866111
DOI  :  10.1186/1750-1326-4-38

 received in 2009-08-01, accepted in 2009-09-28,  发布年份 2009

【 摘 要 】

The nematode worm Caenorhabditis elegans has become an intensely studied model organism, and worm studies have made significant contributions to developmental biology and other fields. The experimental advantages of C. elegans, particularly its simple anatomy, optical transparency, short lifespan, and facile genetics, have also led researchers to use this model to investigate neuronal cell degeneration and death. Worm studies of neurodegeneration can be divided into two general classes: studies in which mutations of C. elegans genes lead to neuronal dysfunction and death, and studies in which external manipulations (e.g., chemical treatments or introduction of engineered transgenes) are used to induce neurodegeneration. For both types of studies the primary approach has been to use forward genetic, reverse genetic, or candidate gene approaches to identify genes that modify neurodegeneration. The ease and relatively low cost of C. elegans propagation also suggests a role for these C. elegans models for compound screening. An excellent review has been previously published that summarizes much of the work done on mutationally-induced neuronal death in C. elegans [1]. This review focuses on studies that have attempted to model specific human neurodegenerative diseases using transgenic approaches. These studies have given us a variety of insights into the specific disruptions of cellular processes that may underlie human neurodegenerative diseases.

【 授权许可】

   
2009 Teschendorf and Link; licensee BioMed Central Ltd.

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