Musical patterns for comparative epigenomics

Clinical Epigenetics

David Brocks¹ 

[1] Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

关键词: Cancer;    Epigenetics;    Transformation;    Music;    DNA methylation;   

Others  :  1225845
DOI  :  10.1186/s13148-015-0127-8

 received in 2015-03-05, accepted in 2015-08-28,  发布年份 2015

【 摘 要 】

Scientific data has been transformed into music in order to raise awareness in the non-scientific community. While the general public is nowadays familiar with the genetic code, there is still a lack of knowledge regarding epigenetic regulation. By making use of the binary nature of the methylome, we here describe a method that transforms methylation patterns into music. The resulting musical pieces show decent complexity and allow the audible recognition between music and underlying methylation state. This approach might therefore facilitate the recognition of complex methylation patterns and increase awareness for epigenetic regulation in the general public.

【 授权许可】

   
2015 Brocks.

【 图 表 】

Fig. 1.

Fig. 2.

【 参考文献 】

• [1]Kata A: A postmodern Pandora’s box: anti-vaccination misinformation on the Internet. Vaccine 2010, 28:1709-16.
• [2]Berkman MB, Plutzer E: Science education. Defeating creationism in the courtroom, but not in the classroom. Science 2011, 331:404-5.
• [3]Guo M: Living in denial: climate change, emotions, and everyday life. J Environ Qual 2013, 42:292.
• [4]Meldolesi A: Italian public votes out anti-GMO Greens. Nat Biotechnol 2001, 19:603-4.
• [5]Ernst E: The role of complementary and alternative medicine in cancer. Lancet Oncol 2000, 1:176-80.
• [6]Turgut H: The context of demarcation in nature of science teaching: the case of astrology. Sci Educ-Netherlands 2011, 20:491-515.
• [7]Takahashi R, Miller JH: Conversion of amino-acid sequence in proteins to classical music: search for auditory patterns. Genome Biol 2007, 8:405. BioMed Central Full Text
• [8]Larsen P, Gilbert J: Microbial bebop: creating music from complex dynamics in microbial ecology. PLoS One 2013., 8Article ID e58119
• [9]Ohno S: A song in praise of peptide palindromes. Leukemia 1993, 7 Suppl 2:S157-9.
• [10]Smallwood SA, Lee HJ, Angermueller C, Krueger F, Saadeh H, Peat J, Andrews SR, Stegle O: Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity. Nat Methods 2014, 11:817-20.
• [11]Landau DA, Clement K, Ziller MJ, Boyle P, Fan J, Gu H, Stevenson K, Sougnez C: Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell 2014, 26:813-25.
• [12]Miyamoto K, Fukutomi T, Akashi-Tanaka S, Hasegawa T, Asahara T, Sugimura T, Ushijima T: Identification of 20 genes aberrantly methylated in human breast cancers. Int. J. Cancer 2005, 116:407-14.
• [13]Waha A, Güntner S, Huang TH, Yan PS, Arslan B, Pietsch T, Wiestler OD, Waha A: Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas. Neoplasia 2005, 7:193-9.
• [14]Brocks D, Assenov Y, Minner S, Bogatyrova O, Simon R, Koop C, Oakes C, Zucknick M: Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer. Cell Reports 2014, 8:798-806.
• [15]Khatib F, DiMaio F, Cooper S, Kazmierczyk M, Gilski M: Foldit Contenders GroupFoldit Void Crushers Group: Crystal structure of a monomeric retroviral protease solved by protein folding game players. Nat Struct Mol Biol 2011, 18:1175-7.
• [16]Larsen JE, Minna JD: Molecular biology of lung cancer: clinical implications. Clin Chest Med 2011, 32:703-40.