Association between serum uric acid level and metabolic syndrome components

Journal of Diabetes & Metabolic Disorders

Saeed Hosseini²  Hamid Asayesh⁵  Roya Kelishadi⁶  Shideh Nikoohemat¹  Mostafa Qorbani⁴  Asal Ataie-Jafari³  Sara Nejatinamini³ 

[1] Department of Cardiology, Mazandaran University of Medical Sciences, Sari, Iran;Endocrinology and Metabolism Research Center (EMRC) Institute, Dr Shariati Hospital, Tehran University of Medical Sciences, North Kargar St, Tehran, Iran;Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Baghestan Boulevard, Karaj, Iran;Department of Medical Emergency, Qom University of Medical Sciences, Qom, Iran;Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

关键词: Body composition;    Insulin resistance;    Metabolic syndrome;    Uric acid;   

Others  :  1224979
DOI  :  10.1186/s40200-015-0200-z

 received in 2015-05-21, accepted in 2015-09-05,  发布年份 2015

【 摘 要 】

Background

Serum uric acid levels is reported to be associated with a variety of cardiometabolic risk factors; however, its direct association with metabolic syndrome (MetS) remains controversial. Thus, we examined the association of serum uric acid concentrations with the MetS components.

Methods

MetS was defined according to the National Cholesterol Education Program (NCEP) criteria. This case–control study comprised 101 non-smoking individuals (41 in the MetS group and 60 in the non-MetS group). Blood pressure, fasting plasma glucose, insulin, HOMA-IR, lipid profiles, uric acid, and anthropometric measures were determined, and body composition was assessed by using bioelectrical impedance analysis (BIA).

Results

After adjustment for confounding factors, serum uric acid was significantly higher in MetS group than non-MetS group (5.70 ± 1.62 vs 4.97 ± 1.30 mg/dL, respectively, P = 0.001). After controlling for age, sex and body mass index in partial correlation analysis, uric acid was positively correlated with triglycerides, and negatively with HDL-C. In multiple logistic regression analysis, every 1 mg/dl elevation in the serum uric acid level increased the risk of MetS approximately by 2-folds (OR: 2.11, 95 % CI: 1.30-3.41).

Conclusion

This study showed that those individuals with MetS have higher uric acid levels; the association of uric acid and MetS components supports that it might be an additional components of MetS.

【 授权许可】

   
2015 Nejatinamini et al.

【 图 表 】

Fig. 1.

Fig. 2.

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