International Journal of Health Geographics | |
Mercury in fish and adverse reproductive outcomes: results from South Carolina | |
Erik Svendsen8  John Vena4  Wilfried Karmaus3  Rebecca Wilkerson1  Bo Cai6  Robin Puett2  Sara Wagner Robb7  James B Burch5  | |
[1] Institute for Families in Society, University of South Carolina, Columbia, SC, USA;Maryland Institute for Applied Environmental Health, University of Maryland, College Park, MD, USA;Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA;Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA;WJB Dorn Veteran’s Affairs Medical Center, Columbia, SC, USA;Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA;College of Public Health, Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, USA;Department of Global Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA | |
关键词: Preterm birth; Geographic information system; Environmental public health tracking; Low birth weight; | |
Others : 1146062 DOI : 10.1186/1476-072X-13-30 |
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received in 2014-04-17, accepted in 2014-07-21, 发布年份 2014 | |
【 摘 要 】
Background
Mercury is a metal with widespread distribution in aquatic ecosystems and significant neurodevelopmental toxicity in humans. Fish biomonitoring for total mercury has been conducted in South Carolina (SC) since 1976, and consumption advisories have been posted for many SC waterways. However, there is limited information on the potential reproductive impacts of mercury due to recreational or subsistence fish consumption.
Methods
To address this issue, geocoded residential locations for live births from the Vital Statistics Registry (1995–2005, N = 362,625) were linked with spatially interpolated total mercury concentrations in fish to estimate potential mercury exposure from consumption of locally caught fish. Generalized estimating equations were used to test the hypothesis that risk of low birth weight (LBW, <2,500 grams) or preterm birth (PTB, <37 weeks clinical gestation) was greater among women living in areas with elevated total mercury in fish, after adjustment for confounding. Separate analyses estimated term LBW and PTB risks using residential proximity to rivers with fish consumption advisories to characterize exposure.
Results
Term LBW was more likely among women residing in areas in the upper quartile of predicted total mercury in fish (odds ratio [OR] = 1.04; 95% confidence interval [CI]: 1.00-1.09) or within 8 kilometers of a river with a ‘do not eat’ fish advisory (1.05; 1.00-1.11) compared to the lowest quartile, or rivers without fish consumption restrictions, respectively. When stratified by race, risks for term LBW or PTB were 10-18% more likely among African-American (AA) mothers living in areas with the highest total fish mercury concentrations.
Conclusions
To our knowledge, this is the first study to examine the relationship between fish total mercury concentrations and adverse reproductive outcomes in a large population-based sample that included AA women. The ecologic nature of exposure assessment in this study precludes causal inference. However, the results suggest a need for more detailed investigations to characterize patterns of local fish consumption and potential dose–response relationships between mercury exposure and adverse reproductive outcomes, particularly among AA mothers.
【 授权许可】
2014 Burch et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20150403090904817.pdf | 1226KB | download | |
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【 图 表 】
Figure 1.
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