A comparison of bivariate and univariate QTL mapping in livestock populations

Genetics Selection Evolution

Daniel Sorensen¹  Just Jensen¹  Bernt Guldbrandtsen¹  Mogens Sandø Lund¹  Peter Sørensen¹ 

[1] Danish Institute of Agricultural Sciences, Department of Animal Breeding and Genetics, Research Centre Foulum, PO Box 50, 8830 Tjele, Denmark

关键词: livestock;    QTL mapping;    multivariate;   

Others  :  1094390
DOI  :  10.1186/1297-9686-35-7-605

 received in 2002-04-22, accepted in 2003-03-06,  发布年份 2003

【 摘 要 】

This study presents a multivariate, variance component-based QTL mapping model implemented via restricted maximum likelihood (REML). The method was applied to investigate bivariate and univariate QTL mapping analyses, using simulated data. Specifically, we report results on the statistical power to detect a QTL and on the precision of parameter estimates using univariate and bivariate approaches. The model and methodology were also applied to study the effectiveness of partitioning the overall genetic correlation between two traits into a component due to many genes of small effect, and one due to the QTL. It is shown that when the QTL has a pleiotropic effect on two traits, a bivariate analysis leads to a higher statistical power of detecting the QTL and to a more precise estimate of the QTL's map position, in particular in the case when the QTL has a small effect on the trait. The increase in power is most marked in cases where the contributions of the QTL and of the polygenic components to the genetic correlation have opposite signs. The bivariate REML analysis can successfully partition the two components contributing to the genetic correlation between traits.

【 授权许可】

   
2003 INRA, EDP Sciences