Spectrum of prostatic lesions

International Archives of Medicine

Anum Mughal¹  Shafaq Saleem¹  Hiba Arshad Shaikh¹  Naseem Ahmad Shaikh¹  Nazish Shahid¹  Hafiz Muhammad Aslam¹ 

[1] Department of Pathology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan

关键词: Prostate;    Prostatic carcinoma;    Prostatic hyperplasia;   

Others  :  802998
DOI  :  10.1186/1755-7682-6-36

 received in 2013-05-29, accepted in 2013-09-21,  发布年份 2013

【 摘 要 】

Background

Prostate gland of male reproductive system is about the size of walnut and surrounds the urethra. Most frequently encountered diseases affecting prostate are Prostatitis, Benign prostatic hyperplasia and Prostatic cancer .Our objective of study was to evaluate the spectrum and correlation of prostatic lesions with presenting complaints of patient.

Methods

It was a cross-sectional study conducted in Pathology Department of Dow Medical College, Dow University of Health Sciences during the period of 1^st January 2010 to December 2012. Pathology department of Dow Medical College collected specimens from both Civil Hospital and Lyari General Hospital Karachi, Pakistan. Specimens were taken through transurethral resection of prostate (TURP), simple prostatectomy and radical prostatectomy. A questionnaire was made and information including name, age, ward name of hospital, laboratory number, clinical diagnosis and symptoms were noted in it. Data was entered and analyzed through SPSS 19.

Result

During the targeted months, 48 prostatic specimens were received with a mean age of 65.7 + -7.6 years. Common presenting complains were urinary retention in 23(47.9%) patients, followed by dribbling in 12(25%). Out of 48 patients, 42 have Benign Prostatic Hyperplasia and 6 have Prostatic Adenocarcinoma. Both Benign Prostatic Hyperplasia and Prostatic Adenocarcinoma were more prevalent in the age group of 60-70 years.

Conclusion

Frequency of prostatic cancer is on the rise and measures should be taken for its early detection. Screening protocols and awareness programs need to be introduced. Screening programs should be focused on level of androgens and molecular pathogenesis.

【 授权许可】

   
2013 Aslam et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Anunobi CC, Akinde OR, Elesha SO, Daramola AO, Tijani KH, Ojewola RW: Prostate diseases in Lagos, Nigeria: a histologic study with tPSA correlation. Nigerian Postgrad Med J 2011, 18(2):98-104.
• [2]Prostatitis Difficult to Diagnose and Treat. http://prostatitis.org/?gclid=CKiWspf0mrUCFYJBzQodfS8AxQ webcite
• [3]Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin 2013, 63(1):11-30.
• [4]Abrar Barakzai Muhammed MM, Iqbal KJ: Histopathological lesions in transrectal ultrasound guided biopsies of prostate in patients with raised serum prostate specific antigen: a preliminary report. J Nephro-Urology Monthly 2011, 3(3):186-190.
• [5]Prostate. http://www.srhmatters.org/sexual-health/prostate/ webcite
• [6]Hameed S, Malik A, Bilal S, Dogar S, Aslam S: Pattern of prostatic disease; a histopathological survey. Professional Med J 2010, 17(4):573-577.
• [7]Benign Prostatic Hyperplasia (BPH). http://www.merckmanuals.com/professional/genitourinary_disorders/benign_prostate_disease/benign_prostatic_hyperplasia_bph.html webcite
• [8]Verhamme KM, Dieleman JP, Bleumink GS, van der Lei J, Sturkenboom MC, Artibani W, Begaud B, Berges R, Borkowski A, Chappel CR, et al.: Incidence and prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in primary care–the Triumph project. Eur Urol 2002, 42(4):323-328.
• [9]Prostate Cancer Risk Factors. http://www.pcf.org/site/c.leJRIROrEpH/b.5802027/k.D271/Prostate_Cancer_Risk_Factors.htm webcite
• [10]Kumar V, Abbas AK, Fausto N, Aster JC: Robbins & Cotran Pathologic Basis of Disease. Cambridge: Elsevier Health Sciences; 2009.
• [11]George E, Thomas S: A Histopathologic Survey of Prostate Disease in The Sultanate of Oman. Journal of Pathology: The Internet; 2009.
• [12]Manjit Singh Bal SK, Goyal AK, Singla N: Prostatic lesion in surgical biopsy lesion. JK-practitioner 2011, 16(1-2):33-34.
• [13]Mansoor I: Pattern of prostatic diseases in Saudi Arabia. Int J Pathol 2003, 2:2.
• [14]Anjorin A, Adeniji K, Ogunsulire I: A histopathological study of prostatic lessons in Ilorin, Nigeria. Cent Afr J Med 1998, 44:3-I998.
• [15]Steers WD, Zorn B: Benign prostatic hyperplasia. Dis Mon 1995, 41(7):437-497.
• [16]Simpson R: Benign prostatic hyperplasia. Br J Gen Pract 1997, 47(417):235.
• [17]Anim J, Ebrahim B, Abdul Sathar S: Benign disorders of the prostate: a histopathological study. Ann Saudi Med 1998, 18:22-27.
• [18]Litwin MS, Saigal CS (Eds): Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms and Bladder Stones In Urologic Diseases in America. US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Washington, DC: US Government Printing Office; 2012. NIH Publication No. 12-7865
• [19]Dennis LK, Lynch CF, Torner JC: Epidemiologic association between prostatitis and prostate cancer. Urology 2002, 60(1):78-83.