Genetic and environmental influences on eating behaviors in 2.5- and 9-year-old children: a longitudinal twin study

International Journal of Behavioral Nutrition and Physical Activity

Daniel Pérusse⁴  Michel Boivin¹  Richard Tremblay²  Bénédicte Fontaine-Bisson⁵  Jaakko Kaprio⁷  Brigitte Bédard⁶  Maikol Diasparra⁶  Lise Dubois³ 

[1] École de psychologie, Université Laval, 2325 rue des Bibliothèques, Québec, QC, Canada;School of Public Health, Physiotherapy & Population Science, University College Dublin, Dublin, Ireland;Department of Epidemiology & Community Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON, Canada;Département d’anthropologie, Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, QC, Canada;Nutrition Sciences Program, University of Ottawa, 25 University Private, Ottawa, ON, Canada;Institute of Population Health, University of Ottawa, 1 Stewart St., Ottawa, ON, Canada;Institute for Molecular Medicine (FIMM), University of Helsinki, P.O. Box 20, Tukholmankatu 8, Helsinki, Finland

关键词: Twins;    Children;    Environmental influences;    Heritability;    Eating behaviors;   

Others  :  805901
DOI  :  10.1186/1479-5868-10-134

 received in 2013-03-11, accepted in 2013-12-02,  发布年份 2013

【 摘 要 】

Background

Eating behaviors during childhood are related both to children’s diet quality and to their weight status. A better understanding of the determinants of eating behavior during childhood is essential for carrying out effective dietary interventions.

Methods

We assessed the contribution of genetic and environmental factors to variations in selected eating behaviors in early and late childhood. Information on eating behaviors came from questionnaires administered to parents of children participating in the Quebec Newborn Twin Study when the twins were 2.5 and 9 years old (n = 692 children). Dichotomous variables were derived and analyzed using structural equation modeling, as part of a classic twin study design. We performed univariate and bivariate longitudinal analyses to quantify sources of variation and covariation across ages, for several eating behavior traits.

Results

We found moderate to strong heritability for traits related to appetite such as eating too much, not eating enough and eating too fast. Univariate analysis estimates varied from 0.71 (95% CI: 0.49, 0.87) to 0.89 (0.75, 0.96) in younger children and from 0.44 (0.18, 0.66) to 0.56 (0.28, 0.78) in older children. Bivariate longitudinal analyses indicated modest to moderate genetic correlations across ages (r_A varying from 0.34 to 0.58). Common genetic influences explained 17% to 43% of the phenotypic correlation between 2.5 and 9 years for these appetite-related behaviors. In 9-year-old children, food acceptance traits, such as refusing to eat and being fussy about food, had high heritability estimates, 0.84 (0.63, 0.94) and 0.85 (0.59, 0.96) respectively, while in younger children, the shared environment (i.e., common to both twins) contributed most to phenotypic variance. Variances in meal-pattern-related behaviors were mostly explained by shared environmental influences.

Conclusions

Genetic predispositions explain a large part of the variations in traits related to appetite during childhood, though our results suggest that as children get older, appetite-related behaviors become more sensitive to environmental influences outside the home. Still, for several traits environmental influences shared by twins appear to have the largest relative importance. This finding supports the notion that familial context has considerable potential to influence the development of healthy eating habits throughout childhood.

【 授权许可】

   
2013 Dubois et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Dubois L, Farmer AP, Girard M, Peterson K: Preschool children’s eating behaviours are related to dietary adequacy and body weight. Eur J Clin Nutr 2007, 61(7):846-855.
• [2]Dubois L, Farmer A, Girard M, Peterson K, Tatone-Tokuda F: Problem eating behaviors related to social factors and body weight in preschool children: a longitudinal study. Int J Behav Nutr Phys Act 2007, 4:9. BioMed Central Full Text
• [3]Dubois L, Girard M, Potvin Kent M, Farmer A, Tatone-Tokuda F: Breakfast skipping is associated with differences in meal patterns, macronutrient intakes and overweight among pre-school children. Public Health Nutr 2009, 12(1):19-28.
• [4]WHO: Diet, nutrition and the prevention of chronic diseases. Report of a Joint WHO/FAO Expert Consultation. WHO Tech Rep Ser 2003, 916(i-vii):1-149.
• [5]Silventoinen K, Rokholm B, Kaprio J, Sørensen TI: The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes (Lond) 2010, 34(1):29-40.
• [6]Klump KL, Burt SA, McGue M, Iacono WG: Changes in genetic and environmental influences on disordered eating across adolescence: a longitudinal twin study. Arch Gen Psychiatry 2007, 64(12):1409-1415.
• [7]Keller KL, Pietrobelli A, Faith MS: Genetics of food intake and body composition: lessons from twin studies. Acta Diabetol 2003, 40(Suppl 1):95-100.
• [8]Llewellyn CH, van Jaarsveld CH, Boniface D, Carnell S, Wardle J: Eating rate is a heritable phenotype related to weight in children. Am J Clin Nutr 2008, 88(6):1560-1566.
• [9]Carnell S, Haworth CM, Plomin R, Wardle J: Genetic influence on appetite in children. Int J Obes (Lond) 2008, 32(10):1468-1473.
• [10]Llewellyn CH, van Jaarsveld CH, Johnson L, Carnell S, Wardle J: Nature and nurture in infant appetite: analysis of the Gemini twin birth cohort. Am J Clin Nutr 2010, 91(5):1172-1179.
• [11]Cooke LJ, Haworth CM, Wardle J: Genetic and environmental influences on children’s food neophobia. Am J Clin Nutr 2007, 86(2):428-433.
• [12]Carnell S, Wardle J: Appetitive traits and child obesity: measurement, origins and implications for intervention. Proc Nutr Soc 2008, 67(4):343-355.
• [13]Fisher JO, Cai G, Jaramillo SJ, Cole SA, Comuzzie AG, Butte NF: Heritability of hyperphagic eating behavior and appetite-related hormones among Hispanic children. Obesity (Silver Spring) 2007, 15(6):1484-1495.
• [14]Reed DR, Tanaka T, McDaniel AH: Diverse tastes: Genetics of sweet and bitter perception. Physiol Behav 2006, 88(3):215-226.
• [15]Birch LL, Davison KK: Family environmental factors influencing the developing behavioral controls of food intake and childhood overweight. Pediatr Clin North Am 2001, 48(4):893-907.
• [16]Keski-Rahkonen A, Viken RJ, Kaprio J, Rissanen A, Rose RJ: Genetic and environmental factors in breakfast eating patterns. Behav Genet 2004, 34(5):503-514.
• [17]Boivin M, Brendgen M, Dionne G, Dubois L, Pérusse D, Robaey P, Tremblay RE, Vitaro F: The Quebec Newborn Twin Study into adolescence: 15 years later. Twin Res Hum Genet 2013, 16(1):64-69.
• [18]Forget-Dubois N, Pérusse D, Turecki G, Girard A, Billette JM, Rouleau G, Boivin M, Malo J, Tremblay RE: Diagnosing zygosity in infant twins: physical similarity, genotyping, and chorionicity. Twin Res 2003, 6:479-485.
• [19]Department of Social Medicine, University of Bristol: Avon Longitudinal Study of Parents and Children (ALSPAC). [http://www.bristol.ac.uk/alspac/ webcite]
• [20]Institut de la statistique du Québec: I am, I’ll be – Québec Longitudinal Study of Child Development (QLSCD). [http://www.iamillbe.stat.gouv.qc.ca/default_an.htm webcite]
• [21]van Dongen J, Slagboom PE, Draisma HH, Martin NG, Boomsma DI: The continuing value of twin studies in the omics era. Nat Rev Genet 2012, 13(9):640-653.
• [22]Boomsma D, Busjahn A, Peltonen L: Classical twin studies and beyond. Nat Rev Genet 2002, 3:872-882.
• [23]Rijsdijk FV, Sham PC: Analytic approaches to twin data using structural equation models. Brief Bioinform 2002, 3(2):119-133.
• [24]Neale MC, Cardon LR: Methodology for Genetic Studies of Twins and Families. Dordrecht: Kluwer Academic Publishers; 1992.
• [25]Eley TC: Sex-limitation models. In Encyclopedia of Behavioural Statistics. Edited by Everitt BJ, Howell D. West Sussex, UK: Wiley; 2005.
• [26]Posthuma D, Beem AL, de Geus EJ, van Baal GC, von Hjelmborg JB, Iachine I, Boomsma DI: Theory and practice in quantitative genetics. Twin Res 2003, 6(5):361-376.
• [27]Neale MC, Eaves LJ, Kendler KS: The power of the classical twin study to resolve variation in threshold traits. Behav Genet 1994, 24(3):239-258.
• [28]OpenMx – Advanced structural equation modeling: OpenMx – Advanced Structural Equation Modeling. [http://openmx.psyc.virginia.edu/ webcite]
• [29]Rolls BJ, Engell D, Birch LL: Serving portion size influences 5-year-old but not 3-year-old children’s food intakes. J Am Diet Assoc 2000, 100(2):232-234.
• [30]Ashcroft J, Semmler C, Carnell S, van Jaarsveld CH, Wardle J: Continuity and stability of eating behaviour traits in children. Eur J Clin Nutr 2008, 62(8):985-990.
• [31]Fisher JO, Birch LL: Eating in the absence of hunger and overweight in girls from 5 to 7 y of age. Am J Clin Nutr 2002, 76(1):226-231.
• [32]Plomin R, Rowe DC: A twin study of temperament in young children. J Psychol 1977, 97:107-113.
• [33]Jones LR, Steer CD, Rogers IS, Emmett PM: Influences on child fruit and vegetable intake: sociodemographic, parental and child factors in a longitudinal cohort study. Public Health Nutr 2010, 13(7):1122-1130.
• [34]Galloway AT, Fiorito L, Lee Y, Birch LL: Parental pressure, dietary patterns, and weight status among girls who are “picky eaters”. J Am Diet Assoc 2005, 105(4):541-548.
• [35]Cooke L, Carnell S, Wardle J: Food neophobia and mealtime food consumption in 4–5 year old children. Int J Behav Nutr Phys Act 2006, 3:14. BioMed Central Full Text
• [36]Mennella JA, Pepino MY, Reed DR: Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005, 115(2):e216-e222.
• [37]Breen FM, Plomin R, Wardle J: Heritability of food preferences in young children. Physiol Behav 2006, 88:443-447.
• [38]Savage JS, Fisher JO, Birch LL: Parental influence on eating behavior: conception to adolescence. J Law Med Ethics 2007, 35(1):22-34.
• [39]Johnson W, Turkheimer E, Gottesman II, Bouchard TJ Jr: Beyond heritability: twin studies in behavioral research. Curr Dir Psychol Sci 2009, 18:217-220.